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Complejos de Ag(i) funcionalizados con pirazolilo-NHC: síntesis, caracterización, actividad antibacteriana e

Ngonidzashe Ruwizhi¹, Karen Pillay², Janade Moodley²

¹School of Agriculture and Science, Discipline of Chemistry, University of KwaZulu-Natal Westville Campus, Private Bag X54001 Durban 4000 South Africa.

|December 24, 2025

Resumen

Se sintetizaron cinco nuevas sales de azolio funcionalizadas con pirazolilo y sus complejos de carbeno de N-heterociclo de plata(I) y se probaron para determinar su actividad antibacteriana. El compuesto 2c, que presenta un sustituyente N-bencilo, mostró una potencia significativa contra las bacterias.

Sus antecedentes:

Los carbenos de N-heterociclo (NHC) son ligandos versátiles en química de coordinación y catálisis.
Las sales de azolio funcionalizadas con pirazolilo y sus complejos metálicos se exploran para diversas actividades biológicas.
El desarrollo de nuevos agentes antibacterianos es crucial debido a la creciente resistencia a los antimicrobianos.

Conclusiones:

Los complejos de carbeno de N-heterociclo de plata(I) funcionalizados con pirazolilo representan una clase prometedora de agentes antibacterianos.
El sustituyente N-bencilo y el andamio de benzimidazol contribuyen significativamente a una mayor eficacia antibacteriana.
La investigación adicional sobre estos compuestos podría conducir al desarrollo de nuevas estrategias terapéuticas contra las infecciones bacterianas.

Palabras clave:

carbenos de N-heterociclo complejos de plata actividad antibacteriana sales de azolio funcionalización con pirazolilo

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