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Updated: Jan 8, 2026
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Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon
Published on: October 29, 2021
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Polipéptidos de hueso de salmón fosforilados: mejora de la estabilidad y la actividad antimicrobiana mediante la
Lingyu Han1, Nuo Dong1, Bing Hu1
1Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian, Liaoning 116600, China.
Food chemistry: X
|December 24, 2025
Resumen
Los péptidos de hueso de salmón se fosforilaron y quelaron con zinc, creando un suplemento estable y bioactivo. Este novedoso suplemento de zinc muestra propiedades antibacterianas y es seguro para uso oral en el procesamiento de alimentos.
Área de la Ciencia:
- Biotecnología marina
- Ciencia de biomateriales
- Bioquímica nutricional
Sus antecedentes:
- Los huesos de salmón representan una valiosa corriente de residuos marinos con un potencial bioactivo sin explotar.
- La fosforilación y la quelación de metales pueden mejorar las propiedades funcionales de las biomoléculas.
Objetivo del estudio:
- Desarrollar y caracterizar péptidos de hueso de salmón fosforilados quelados con zinc (P-SBPs-Zn).
- Evaluar la estabilidad, digestibilidad, actividad antibacteriana y seguridad de P-SBPs-Zn para posibles aplicaciones alimentarias.
Principales métodos:
- Los péptidos de hueso de salmón (SBPs) se fosforilaron a varios niveles de pH.
- Análisis estructural mediante espectroscopía infrarroja con transformada de Fourier, espectroscopía de fluorescencia y espectroscopía de CD.
- Se realizaron ensayos de eficiencia de quelación de zinc, estabilidad, digestibilidad, actividad antibacteriana y seguridad celular.
Principales resultados:
- Los quelatos de fosfopéptido-zinc a pH 4 (P-SBPs4-Zn) mostraron una solubilidad y capacidad de unión de zinc superiores (86,15 ± 0,47 mg/g de zinc).
- P-SBPs4-Zn exhibió una excelente estabilidad y digestibilidad en condiciones gastrointestinales simuladas.
- Se observaron efectos antibacterianos significativos contra Escherichia coli y Staphylococcus aureus, atribuidos a la disrupción de la membrana.
- Las evaluaciones de seguridad confirmaron la biocompatibilidad con las células Caco-2 y RAW 264.7.
Conclusiones:
- P-SBPs4-Zn es un suplemento de zinc altamente eficaz, estable y biocompatible derivado de residuos marinos.
- Este novedoso complejo de fosfopéptido-zinc demuestra potencial como agente antibacteriano e ingrediente funcional en el procesamiento de alimentos.
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