Video Experimental Relacionado

Updated: Jan 8, 2026

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)

Published on: August 9, 2024

LRRC8A: Un regulador multifacético en el cáncer, trastornos neurológicos, enfermedades metabólicas y modulación

Longjun Yang¹, Qiang Ding¹, Xiaoyu Ji¹

¹Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Department of Gastroenterology, Wuhan, Hubei 430000, China.

Genes & diseases

|December 24, 2025

Abstract:

Leucine-rich repeat containing 8A (LRRC8A) is a member of the LRRC8 family, exhibiting broad expression across various tissues and cells in vertebrates. Like other LRRC8 family members, LRRC8A contributes to the formation of volume-regulated anion channels (VRACs), which are crucial for regulating cell volume and maintaining homeostasis. LRRC8A participates in diverse signaling pathways. Multiple studies have validated the links between LRRC8A dysregulation and neurological disorders, metabolic ailments, and tumors. This review provides a comprehensive overview of the regulatory mechanisms of LRRC8A in these pathologies. The primary goal was to assess the potential of LRRC8A as a therapeutic target for treating diseases and address key unresolved issues.

Palabras clave:

Inmunidad LRRC8A Mecanismo molecular Estructura VRAC

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