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Enfermedad de Castleman Multicéntrica Idiopática con Eosinofilia Severa y Nódulo Centrilobular Difuso: Un Informe de
Xiaojuan Li1, Shuang Li2, Tianming Zhao1,3
1Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China, ctgu.edu.cn.
Case reports in hematology
|December 24, 2025
Resumen
La enfermedad de Castleman multicéntrica idiopática (iMCD) raramente se presenta con eosinofilia severa y nódulos pulmonares. La terapia temprana con corticosteroides mejoró significativamente los síntomas y normalizó los recuentos de eosinófilos en este caso único.
Área de la Ciencia:
- Informes de Casos Médicos
- Hematología
- Neumología
Sus antecedentes:
- La enfermedad de Castleman multicéntrica idiopática (iMCD) es un trastorno linfoproliferativo raro con manifestaciones clínicas variadas.
- La eosinofilia severa y los nódulos pulmonares difusos son presentaciones infrecuentes de la iMCD.
Objetivo del estudio:
- Informar un caso raro de iMCD que se presenta con eosinofilia severa y afectación pulmonar.
- Destacar los desafíos diagnósticos y los resultados del tratamiento en una presentación tan rara.
Principales métodos:
- Se evaluó a un paciente varón de 69 años con síntomas de fiebre, tos y disnea.
- El estudio diagnóstico incluyó pruebas de laboratorio, TC de tórax y biopsia de ganglio linfático axilar.
- El paciente fue tratado con metilprednisolona tras excluir otras causas de eosinofilia.
Principales resultados:
- El paciente presentó eosinofilia severa y nódulos intersticiales pulmonares bilaterales.
- La biopsia de ganglio linfático confirmó iMCD con infiltración eosinofílica.
- El tratamiento con corticosteroides condujo a una marcada mejoría de los síntomas, normalización de los recuentos de eosinófilos y reducción de los marcadores inflamatorios.
Conclusiones:
- Este caso subraya la importancia de considerar la iMCD en pacientes con eosinofilia inexplicable y síntomas pulmonares.
- El reconocimiento temprano y la iniciación de la terapia con corticosteroides son cruciales para resultados favorables en la iMCD con eosinofilia.
- Este informe contribuye a la limitada literatura sobre iMCD con eosinofilia y afectación pulmonar, ayudando a futuras estrategias de manejo.
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