Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

524
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
524
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

676
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
676
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Cognitive decline in Dutch-type hereditary and sporadic cerebral amyloid angiopathy: a 5-year follow-up study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Impact of plasma pTau181 levels on clinician diagnostic confidence and management in memory and cognition clinics: A multi-site before-and-after study.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Translational Feasibility of Curcumin for Treatment of Alzheimer's Disease: A Critical Appraisal of Clinical Challenges.

Antioxidants (Basel, Switzerland)·2026
Same author

Stage-dependent dynamics of neuroinflammation across the Alzheimer's continuum.

Brain, behavior, and immunity·2026
Same author

Circulating Sphingomyelins Correlate With Plasma T-Tau in Cognitively Unimpaired Older Adults at Risk of Developing Alzheimer's Disease.

Journal of neurochemistry·2026
Same author

Dietary Patterns and Cerebral Glucose Metabolism in Older Adults: Findings from the Western Australian Memory Study.

Nutrients·2026

Video Experimental Relacionado

Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Ciencia básica y patogénesis

Dona P W Jayatunga1,2, Eugene Hone3, Ralph N Martins4,5,6

  • 1Centre of Excellence for Alzheimer's Disease Research & Care, perth, Western Australia, Sri Lanka.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 24, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La patología de la enfermedad de Alzheimer (EA) implica la deposición de péptidos de beta-amiloide (Aβ), lo que conduce a la disfunción mitocondrial. Este estudio muestra que la exposición crónica a Aβ1-42 altera la dinámica mitocondrial, la mitofagia y la biogénesis con el tiempo.

Palabras clave:
Enfermedad de AlzheimerDisfunción mitocondrialBeta-amiloideMitofagiaDinámica mitocondrial

Más Videos Relacionados

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Videos de Experimentos Relacionados

Last Updated: Jan 8, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Área de la Ciencia:

  • Neurociencia
  • Biologรญa celular
  • Bioquรญmica

Sus antecedentes:

  • La enfermedad de Alzheimer (EA) es un trastorno neurodegenerativo prevalente caracterizado por la deposiciรณn de pรฉptidos de beta-amiloide (Aβ).
  • La disfunciรณn mitocondrial es una caracterรญstica patolรณgica clave observada en la EA.

Objetivo del estudio:

  • Investigar los efectos dependientes del tiempo de la toxicidad de Aβ1-42 en los mecanismos de control de calidad mitocondrial.
  • Evaluar el impacto en la dinรกmica mitocondrial, la autofagia selectiva (mitofagia) y la biogรฉnesis mitocondrial en cรฉlulas neuronales.

Principales métodos:

  • Se expusieron cรฉlulas BE(2)-M17 a Aβ1-42 oligomรฉrico durante diferentes perรญodos de tiempo (4-72 horas).
  • Se midieron la actividad mitocondrial, los niveles de ATP y las especies reactivas del oxรญgeno (ROS).
  • Se cuantificaron los niveles de proteรญnas implicadas en la dinรกmica mitocondrial, la mitofagia y la biogรฉnesis mediante Western blots.

Principales resultados:

  • La exposición crรณnica a Aβ1-42 provocรณ un aumento de ROS y una disminuciรณn de los niveles de ATP.
  • Se observaron alteraciones en las proteรญnas de control de calidad mitocondrial con el tiempo.
  • Se evidenciรณ una compromisiรณn de la dinรกmica mitocondrial, la mitofagia y la biogรฉnesis, lo que indica una disfunciรณn mitocondrial progresiva.

Conclusiones:

  • La exposiciรณn crรณnica a Aβ1-42 promueve la disfunciรณn mitocondrial a travรฉs de mecanismos de control de calidad alterados.
  • Se necesita investigaciรณn adicional para determinar si las fluctuaciones observadas representan respuestas celulares adaptativas a la citotoxicidad de Aβ1-42.