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Influencia de la formulación de administración dérmica de retinol en sus características de estabilidad
Ioana Lavinia Lixandru Matei1,2, Bogdan Alexandru Sava2,3, Codruta Sarosi4
1Botanical SRL, 7 Trandafirilor St., 107059 Tătărani, Romania.
Gels (Basel, Switzerland)
|December 24, 2025
Resumen
Se desarrollaron nuevas fórmulas cosmecéuticas que combinan biovidrio y retinol para reducir la irritación del retinoide y mejorar la eficacia. Estas formulaciones estables, que incluyen emulsiones e hidrogeles, muestran características prometedoras para uso terapéutico.
Área de la Ciencia:
- Ciencia cosmética
- Ciencia de materiales
- Dermatología
Sus antecedentes:
- Los retinoides son eficaces pero pueden causar irritación en la piel.
- El biovidrio ofrece beneficios terapéuticos potenciales.
- La combinación de estos podría crear cosmecéuticos mejorados.
Objetivo del estudio:
- Desarrollar y caracterizar formulaciones cosmecéuticas novedosas.
- Combinar biovidrio con retinol en forma de emulsión directa, emulsión inversa e hidrogel.
- Evaluar los efectos sinérgicos sobre la irritación y la eficacia del retinoide.
Principales métodos:
- Preparación y caracterización de formulaciones de emulsión directa, emulsión inversa e hidrogel.
- Análisis Termogravimétrico (TGA) y Calorimetría Diferencial de Barrido (DSC) para evaluar interacciones.
- Pruebas de estabilidad utilizando variación de retrodispersión y análisis de gotas.
Principales resultados:
- La TGA y la DSC indicaron interacciones más fuertes entre el agua y los compuestos orgánicos en las emulsiones en comparación con los hidrogeles, lo que retrasó la evaporación del agua.
- Las formulaciones demostraron alta estabilidad a través del análisis de retrodispersión y gotas.
- La combinación de biovidrio y retinol mostró potencial para reducir la irritación y prolongar la eficacia.
Conclusiones:
- Se desarrollaron con éxito formulaciones cosmecéuticas novedosas que integran biovidrio y retinol.
- Las formulaciones exhibieron una excelente estabilidad fisicoquímica y microbiológica.
- Estos hallazgos sugieren un enfoque prometedor para mitigar la irritación inducida por retinoides y mejorar los resultados terapéuticos.
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