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MicroARNs en la Formación y Progresión de la Metástasis Ósea del Cáncer de Mama: Una Visión General de los Avances

Margherita Puppo¹

¹IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132 Genova, Italy.

|December 24, 2025

Abstract:

Bone metastasis is a common and severe complication in advanced stages of breast cancer (BC) that is characterised by limited treatment options and poor patient prognosis. MicroRNAs (miRNAs) are a large class of regulatory small non-coding RNAs (ncRNAs) expressed by cells. Moreover, miRNAs can be released by cells into the blood and lymphatic streams, acting as distant cell-to-cell communicators. Of note, miRNAs have pivotal roles in the metastatic progression of BC to bone. This review summarises the most recent findings on miRNAs and their mRNA targets in driving BC bone metastasis. Furthermore, the potential clinical uses of miRNAs as future therapeutic targets/agents or biomarkers for BC bone metastasis are discussed.

Palabras clave:

biomarcadores metástasis ósea cáncer de mama miR miRNA microARN ARNnc osteoblasto osteoclasto terapia dirigida

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