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Brittany N Dugger1, Lee-Way Jin2, Viharkumar Patel1

  • 1University of California, Davis, Sacramento, CA, USA.

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Resumen

La neuropatología en individuos diversos de muy avanzada edad revela que la enfermedad de Alzheimer (EA) y las patologías vasculares son comunes. Estos hallazgos resaltan la neuropatología de la EA como un factor clave en el deterioro cognitivo en la edad avanzada.

Palabras clave:
neuropatologíaenfermedad de Alzheimerpatología vascularenvejecimientodeterioro cognitivo

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Área de la Ciencia:

  • Neuropatología; Gerontología; Neurociencia

Sus antecedentes:

  • La comprensión de la neuropatología en los más ancianos es crucial para abordar el deterioro cognitivo relacionado con la edad.
  • La investigación existente a menudo carece de diversidad etnorracial, lo que limita la generalización.
  • Este estudio tiene como objetivo caracterizar las patologías cerebrales en una cohorte diversa de personas muy ancianas.

Objetivo del estudio:

  • Examinar los perfiles neuropatológicos de individuos de 90 años o más, étnica y racialmente diversos.
  • Identificar la prevalencia de patologías neurodegenerativas y vasculares comunes en esta población.
  • Investigar la asociación entre la neuropatología y el estado cognitivo.

Principales métodos:

  • El estudio LifeAfter90 reclutó a personas de 90 años o más de Kaiser Permanente del Norte de California.
  • Los participantes se sometieron a evaluaciones cognitivas y entrevistas regulares.
  • Se facilitó la donación de cerebros para la evaluación neuropatológica utilizando criterios estandarizados.

Principales resultados:

  • De 124 participantes fallecidos con neuropatología completa, las patologías de la enfermedad de Alzheimer (EA) y vasculares fueron las más frecuentes.
  • Si bien las patologías de la EA fueron comunes, las formas graves fueron infrecuentes.
  • Las patologías vasculares como la arteriolosclerosis y la aterosclerosis fueron prevalentes
  • Los cuerpos de Lewy y la LATE-NC fueron menos comunes.

Conclusiones:

  • Esta cohorte diversa de los más ancianos demuestra la presencia de múltiples patologías cerebrales con la edad avanzada.
  • La enfermedad de Alzheimer y ciertas patologías vasculares son contribuyentes significativos al deterioro cognitivo en los muy ancianos.
  • Los hallazgos neuropatológicos subrayan la importancia de la EA en la conducción del deterioro cognitivo en el envejecimiento avanzado.