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Manifestaciones Clínicas

Gaia Chiara Santi1, Eleonora Catricalà2, Stephanie Kwan3

  • 1IRCCS Mondino Foundation, Pavia, Italy.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio revela perfiles semánticos consistentes en la Afasia Primaria Progresiva (APP) en hablantes de inglés, chino e italiano. Las características específicas del lenguaje impactan significativamente la presentación de la APP, lo que requiere criterios de diagnóstico adaptados.

Palabras clave:
Afasia Primaria Progresivalingüísticaneurolingüísticapatología del habla y lenguajetipología del lenguaje

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Área de la Ciencia:

  • Neurolingüística; Patología del Habla y Lenguaje; Lingüística Computacional

Sus antecedentes:

  • La investigación sobre la Afasia Primaria Progresiva (APP) presenta predominantemente cohortes de habla inglesa. La influencia de la tipología del lenguaje en la manifestación clínica de la APP no se comprende bien. Se requieren perfiles de APP translingüísticos utilizando métodos basados en datos.

Objetivo del estudio:

  • Examinar los perfiles de habla y lenguaje en pacientes con APP de inglés, chino e italiano. Identificar similitudes y diferencias translingüísticas en las manifestaciones de la APP. Explorar el impacto de la tipología del lenguaje en los fenotipos de la APP.

Principales métodos:

  • Un enfoque basado en datos utilizando Análisis de Detección de Comunidades (CDA) en muestras de habla de 90 pacientes con APP (30 por idioma). El análisis CLAN caracterizó los dominios fonético-fonológico, léxico-semántico, morfo-sintáctico y del discurso-pragmático. Se compararon los perfiles entre las cohortes de habla inglesa, china e italiana.

Principales resultados:

  • Se observó un clúster semántico consistente en todos los idiomas. La variante no fluente de APP (nfvAPP) y la variante logopénica de APP (lvAPP) mostraron una heterogeneidad significativa. Las características específicas del lenguaje influyeron en la presentación de la APP, por ejemplo, errores de tono en chino, errores morfológicos en italiano.

Conclusiones:

  • La investigación translingüística sobre la APP es crucial para comprender la heterogeneidad de la enfermedad. Las características específicas del lenguaje desempeñan un papel clave en la caracterización clínica de la APP. Los criterios de diagnóstico existentes pueden necesitar adaptación para idiomas distintos del inglés.