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Manifestaciones Clínicas

Alonso Morales-Rivero1, Raul Medina Rioja2, Indira Ruth Garcia Cordero3

  • 1Toronto Western Hospital, University Health Network Memory Clinic, Toronto, ON, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El manejo de la parálisis supranuclear progresiva (PSP) debe abordar los síntomas conductuales y cognitivos, no solo los déficits motores. Este enfoque mejora significativamente la calidad de vida del paciente y la familia.

Palabras clave:
Parálisis Supranuclear Progresivasíntomas neuropsiquiátricossíntomas cognitivosmanejocalidad de vida

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Área de la Ciencia:

  • Neurociencia
  • Neurología
  • Geriatría

Sus antecedentes:

  • La parálisis supranuclear progresiva (PSP) es un trastorno parkinsoniano atípico complejo.
  • Se presenta con disfunción oculomotora, inestabilidad postural, deterioro cognitivo y síntomas neuropsiquiátricos.
  • Los tratamientos actuales se centran principalmente en los síntomas motores, a menudo descuidando aspectos conductuales y cognitivos significativos.

Objetivo del estudio:

  • Destacar la importancia de abordar los síntomas neuropsiquiátricos y cognitivos en la PSP.
  • Introducir herramientas prácticas para la detección de problemas neuropsiquiátricos comunes en pacientes con PSP.
  • Discutir estrategias de manejo farmacológico y no farmacológico para estos síntomas.

Principales métodos:

  • Revisión de herramientas de evaluación para la detección de síntomas neuropsiquiátricos en la PSP.
  • Discusión de tratamientos farmacológicos basados en evidencia (antidepresivos, antipsicóticos, estabilizadores del ánimo).
  • Exploración de intervenciones no farmacológicas para el manejo conductual y cognitivo.

Principales resultados:

  • La evaluación integral es crucial para comprender los impedimentos neuroconductuales multifacéticos en la PSP.
  • El manejo efectivo de la depresión, la apatía, la ansiedad y el deterioro cognitivo puede mejorar la funcionalidad del paciente.
  • Equilibrar la eficacia del tratamiento con los efectos adversos es un desafío clave en la farmacoterapia.

Conclusiones:

  • Abordar los síntomas neuropsiquiátricos y cognitivos en la PSP es vital para mejorar la calidad de vida del paciente y del cuidador.
  • Se recomienda un enfoque multifacético que combine la detección, intervenciones farmacológicas y no farmacológicas.
  • Se justifica una mayor investigación sobre tratamientos adaptados al perfil neuroconductual único de la PSP.