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Manifestaciones Clínicas

Avinash Chandra1, Sheena Waters1, Yue Liu1

  • 1Queen Mary University of London, London, Greater London, United Kingdom.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La disfunción vestibular, indicada por mareos, se relaciona con marcadores tempranos de la enfermedad de Alzheimer, como la patología tau y la atrofia hipocampal en personas cognitivamente normales. Se necesita más investigación para confirmar la relación causal y sus implicaciones para la neurodegeneración.

Palabras clave:
mareosdisfunción vestibularAlzheimer tempranopatología tauatrofia hipocampalneurodegeneración

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Área de la Ciencia:

  • Neurociencia; Neurología; Gerontología

Sus antecedentes:

  • Los déficits del sistema vestibular se asocian con un mayor riesgo de demencia y deterioro cognitivo.; Los mareos subjetivos son un síntoma común de la disfunción vestibular, pero su vínculo neuropatológico con la cognición no está claro.

Objetivo del estudio:

  • Investigar la asociación entre los mareos autoinformados y los marcadores tempranos de neurodegeneración.; Explorar los fundamentos neuropatológicos de cómo la disfunción vestibular puede afectar la cognición.

Principales métodos:

  • Análisis de datos de 1677 participantes en la Iniciativa de Neuroimagen de la Enfermedad de Alzheimer.; Evaluación de mareos autoinformados y otros síntomas vestibulares.; Examen de las asociaciones con marcadores de la enfermedad de Alzheimer (EA) en líquido cefalorraquídeo (LCR), resonancias magnéticas/exploraciones PET, rendimiento cognitivo y biomarcadores.

Principales resultados:

  • En sujetos cognitivamente normales, los mareos con otros síntomas vestibulares se correlacionaron con niveles más altos de t-tau en el LCR.; Los mareos autoinformados en personas cognitivamente normales se asociaron con una menor volumen del hipocampo.; Estas asociaciones mostraron tendencias en grupos combinados de casos cognitivamente normales, deterioro cognitivo leve (DCL) y EA.

Conclusiones:

  • El estudio sugiere posibles marcadores degenerativos tempranos vinculados a la disfunción vestibular, específicamente la patología tau y la atrofia hipocampal.; La direccionalidad de la relación entre el daño vestibular y la neurodegeneración requiere una mayor investigación.; La evaluación de la disfunción vestibular puede ser importante en la evaluación de procesos neurodegenerativos en etapa temprana.