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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Manifestaciones Clínicas

Joseph Eichenbaum1, Miriam T Ashford1,2, Chengshi Jin1

  • 1University of California, San Francisco, San Francisco, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los biomarcadores plasmáticos como pTau217 y GFAP se correlacionan con el deterioro cognitivo subjetivo y las preocupaciones sobre la memoria en adultos mayores. Este método de cribado remoto ayuda a identificar a las personas en riesgo de enfermedad de Alzheimer (EA).

Palabras clave:
biomarcadores plasmáticosdeterioro cognitivo subjetivoAlzheimercribado remotopTau217GFAP

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Área de la Ciencia:

  • Neurología
  • Descubrimiento de biomarcadores
  • Gerontología

Sus antecedentes:

  • Los biomarcadores plasmáticos prometen la detección temprana de la enfermedad de Alzheimer (EA).
  • El Deterioro Cognitivo Subjetivo (SCD) representa una etapa sintomática temprana en el continuo de la EA.
  • La utilidad de los biomarcadores plasmáticos en la población con SCD sigue sin explorarse en profundidad.

Objetivo del estudio:

  • Investigar la relación entre los niveles de biomarcadores de EA en plasma y las medidas cognitivas subjetivas/objetivas en una cohorte remota.
  • Evaluar el potencial de la recopilación de datos remotos escalables para el cribado y seguimiento de la EA.

Principales métodos:

  • 629 participantes (55+) se sometieron a extracciones de sangre remotas para análisis de plasma.
  • Los biomarcadores plasmáticos medidos incluyeron NFL, Aβ42/40, pTau231, pTau217 y GFAP.
  • La regresión lineal analizó las asociaciones entre los biomarcadores y las escalas cognitivas (ECog, preocupaciones de memoria, Cogstate).

Principales resultados:

  • Los niveles elevados de pTau217 y pTau231 se correlacionaron con preocupaciones sobre la memoria autoinformadas.
  • Un mayor nivel de pTau217 y GFAP se asoció con un mayor deterioro cognitivo autoinformado en la escala ECog.
  • No se encontraron asociaciones significativas entre los biomarcadores plasmáticos y el rendimiento cognitivo objetivo (Cogstate).

Conclusiones:

  • Las medidas digitales remotas y no supervisadas de SCD y preocupaciones de memoria pueden identificar a personas con niveles elevados de pTau y GFAP en plasma.
  • Este enfoque identifica de manera eficiente a los adultos mayores en riesgo de deterioro cognitivo relacionado con la EA.
  • El método escalable facilita el reclutamiento para ensayos clínicos, estudios observacionales y cribado de atención clínica.