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Manifestaciones Clínicas

David López-Martos1,2, Mahnaz Shekari1, Gemma Salvadó1,3

  • 1Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La acumulación de amiloide se relaciona con cambios cerebrales específicos en la atención, el control cognitivo y la memoria de trabajo en personas con riesgo de enfermedad de Alzheimer (EA). Estos hallazgos resaltan patrones distintos de deterioro cognitivo que preceden al inicio de la EA.

Palabras clave:
enfermedad de Alzheimeramiloidefunción ejecutivadeterioro cognitivoneuroimagenPETensayos neuropsicológicosestudios longitudinalescohortes

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Área de la Ciencia:

  • Neuroscience; Neurology; Cognitive Science

Sus antecedentes:

  • Subtle cognitive decline, particularly in Executive Function (EF), may precede clinical Alzheimer's disease (AD) onset.; The relationship between pathological Amyloid (Aβ) accumulation and longitudinal changes in EF remains unclear.; Investigating Aβ PET imaging and EF changes in cognitively unimpaired (CU) individuals at risk for AD is crucial.

Objetivo del estudio:

  • To investigate longitudinal Aβ accumulation patterns in relation to EF changes in CU individuals at risk for AD.; To explore voxel-wise associations between Aβ PET imaging and longitudinal changes in attention, cognitive control, and working memory.; To understand the brain regions affected by Aβ accumulation in preclinical AD.

Principales métodos:

  • 187 CU individuals from the ALFA+ cohort underwent CSF sampling, longitudinal Aβ PET scans, and neuropsychological assessments.; Aβ-positivity was determined by CSF Aβ42/40 ratio; EF changes were assessed using standardized indices for attention, cognitive control, and working memory.; Whole-brain voxel-wise linear regression models analyzed change-on-change associations between Aβ accumulation and EF changes.

Principales resultados:

  • 40.64% of participants were Aβ-positive.; Attention decline correlated with parietal and mid-cingulate cortex Aβ accumulation.; Cognitive control decline linked to frontal lobe Aβ accumulation; working memory decline associated with parietal and temporal lobe Aβ accumulation.

Conclusiones:

  • Distinct regional Aβ accumulation patterns are associated with subtle cognitive decline in attention, cognitive control, and working memory in CU individuals.; These findings provide insights into brain regions affected by AD-related EF decline.; Tailored neuropsychological assessments are important for monitoring cognitive changes in preclinical AD.