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Manifestaciones Clínicas

Ileana De Anda-Duran1, Phillip H Hwang2, Elizabeth Leverant3

  • 1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Una prueba digital abreviada Trail Making Test-Part B evalúa eficazmente el deterioro cognitivo leve (MCI) al medir el tiempo dedicado a los objetivos, lo que ayuda en la detección temprana de la enfermedad de Alzheimer.

Palabras clave:
Deterioro cognitivo levePrueba digital Trail Making Test-Part BEnfermedad de AlzheimerDiagnóstico tempranoNeuropsicología

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Área de la Ciencia:

  • Neurociencia; Psicología Cognitiva; Tecnología Médica

Sus antecedentes:

  • Los tratamientos emergentes con anticuerpos monoclonales para la enfermedad de Alzheimer (EA) requieren la identificación temprana del deterioro cognitivo leve (MCI).; Las métricas novedosas de la Prueba Digital Trail Making-Part B (dTMT-B) muestran promesa en la diferenciación de MCI de la cognición normal (NC).

Objetivo del estudio:

  • Evaluar la eficacia de una dTMT-B abreviada para distinguir MCI de NC.; Explorar la relación entre el rendimiento de la dTMT-B abreviada y las pruebas neuropsicológicas tradicionales.

Principales métodos:

  • Se desarrolló una dTMT-B abreviada centrada en la primera mitad de la prueba.; Se recopilaron datos de 58 pacientes de clínicas de memoria clasificados como MCI o NC.; Se analizaron las métricas de proceso: duración del acierto, distancia y velocidad.

Principales resultados:

  • Los pacientes con MCI exhibieron duraciones de aciertos más largas en comparación con los pacientes con NC (p < 0.004).; Una mayor duración de los aciertos se correlacionó con un peor rendimiento en las pruebas de atención, memoria de trabajo y memoria episódica.; No se encontraron diferencias significativas en la distancia total o la velocidad de la velocidad del trazo del lápiz.

Conclusiones:

  • Una Prueba Digital Trail Making-Part B abreviada proporciona métricas novedosas basadas en el proceso para la evaluación cognitiva.; Esta versión abreviada ofrece una herramienta versátil para la detección del deterioro cognitivo emergente.