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Habbiburr Rehman1, Qiushan Tao2, Ting Fang Alvin Ang3,4

  • 1Biomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
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PubMed
Resumen
Este resumen es generado por máquina.

Este estudio revela patrones específicos de atrofia cerebral en resonancias magnéticas relacionados con el deterioro cognitivo leve (DCL) y la demencia. Estos cambios se correlacionan con el deterioro cognitivo y los biomarcadores de la enfermedad de Alzheimer.

Palabras clave:
resonancia magnéticaatrofia cerebraldeterioro cognitivo levedemenciaenfermedad de Alzheimerbiomarcadoresneuroimagenneurología

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Área de la Ciencia:

  • Neuroimaging; Neurology; Biomarkers

Sus antecedentes:

  • Alzheimer's disease (AD) dementia involves abnormal protein buildup and brain cell loss.; The link between brain atrophy progression and dementia/cognitive impairment remains unclear.

Objetivo del estudio:

  • To investigate longitudinal changes in brain atrophy associated with mild cognitive impairment (MCI) and dementia.; To identify specific MRI features and brain regions indicative of cognitive decline.

Principales métodos:

  • Utilized MRI data from Framingham Heart Study participants (n=756).; Employed linear mixed-effects models and Assorted Linear functions for ANOVA Simultaneous Component Analysis (ALASCA) to analyze 1126 MRI features.; Included cognitively normal, MCI, and dementia groups.

Principales resultados:

  • Identified 52 MRI features for MCI and 143 for dementia.; Principal components (PCs) revealed distinct atrophy patterns: M-PC1 and D-PC1 decreased over time in MCI/dementia groups compared to controls.; M-PC2 and D-PC2 showed differing trends between MCI and dementia groups.; PCs correlated significantly with plasma biomarkers (p-tau181, t-tau) and cognitive functions (language, memory, executive function, MMSE).; Key brain regions implicated include hippocampus, amygdala, and pulvinar.

Conclusiones:

  • Specific patterns of brain atrophy in regions like the hippocampus and amygdala are associated with MCI and dementia.; These MRI-derived features aid in understanding dementia heterogeneity and progression.; Findings highlight the role of identified brain regions and biomarkers in cognitive decline.