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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Manifestaciones Clínicas
Gregory L Wallace1, Goldie A McQuaid2, Sean C Duane3
1The George Washington University, Washington D.C., DC, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
Resumen
Los adultos autistas muestran un mayor riesgo de deterioro cognitivo, a menudo relacionado con el uso de medicamentos anticolinérgicos. Este estudio destaca la necesidad de una gestión cuidadosa de la medicación en las poblaciones autistas para mitigar el riesgo de demencia.
Área de la Ciencia:
- Neurociencia; Gerontología; Investigación sobre el Autismo
Sus antecedentes:
- Los datos de reclamaciones de atención médica sugieren que los adultos autistas tienen tasas más altas de diagnósticos relacionados con la demencia. Faltan datos prospectivos sobre el riesgo de deterioro cognitivo y los cribados de demencia en adultos autistas. La alta polifarmacia en adultos autistas puede conducir a una carga anticolinérgica significativa, un factor de riesgo conocido para la demencia.
Objetivo del estudio:
- Evaluar el riesgo de deterioro cognitivo en adultos autistas utilizando cribados de demencia. Documentar la carga de medicación anticolinérgica en adultos autistas. Investigar la asociación entre el deterioro cognitivo y la carga anticolinérgica en adultos autistas.
Principales métodos:
- Se reclutaron dos muestras de adultos autistas a través de SPARK: 210 'independientes' (edad 42-81) y 500 'dependientes' (edad 18-68). El deterioro cognitivo se evaluó utilizando el AD8 (autoevaluado) para adultos independientes y el DSQIID (evaluado por el cuidador) para adultos dependientes. El uso de medicamentos anticolinérgicos se cuantificó utilizando la Escala de Carga Anticolinérgica CRIDECO (CALS).
Principales resultados:
- El 30% de los adultos autistas independientes y el 10-3% de los adultos autistas dependientes mostraron resultados positivos en el cribado de deterioro cognitivo. Más del 63% de los participantes en ambas muestras utilizaron al menos un medicamento anticolinérgico. Una mayor potencia anticolinérgica se asoció significativamente con un aumento en las calificaciones de deterioro cognitivo en ambas muestras (p < .01).
Conclusiones:
- Los cribados de demencia confirman informes comunes de deterioro cognitivo en adultos autistas, alineándose con los datos de reclamaciones. Los adultos autistas exhiben altas tasas de uso de medicamentos anticolinérgicos. Una mayor potencia anticolinérgica se relaciona con informes de deterioro cognitivo en adultos autistas, potencialmente a edades más tempranas que en la población general.
Palabras clave:
deterioro cognitivoautismomedicamentos anticolinérgicosdemenciagestión de la medicaciónMás Videos Relacionados
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