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Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Manifestaciones Clínicas

Cristina A F Román1, Anny Reyes2

  • 1Keck School of Medicine of USC, Los Angeles, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La exclusión de personas con trastornos neurológicos de la investigación sobre el envejecimiento limita la comprensión. La inclusión de estos grupos ofrece perspectivas únicas sobre el envejecimiento cognitivo y el riesgo de demencia, promoviendo la equidad en salud.

Palabras clave:
envejecimientodemenciatrastornos neurológicosinvestigación inclusivadisparidades en saludenvejecimiento cognitivo

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Área de la Ciencia:

  • Gerontología
  • Neurociencia
  • Salud Pública

Sus antecedentes:

  • La investigación sobre el envejecimiento y la demencia a menudo excluye a personas con trastornos neurológicos/médicos, por temor a variables de confusión.
  • Esta exclusión limita la comprensión de los procesos de envejecimiento y la heterogeneidad fenotípica en afecciones como la enfermedad de Alzheimer.
  • Los estudios centrados en estas poblaciones pueden proporcionar información única sobre los mecanismos de envejecimiento y enfermedad.

Objetivo del estudio:

  • Revisar la literatura existente sobre el envejecimiento y la demencia en personas con trastornos neurológicos/médicos específicos.
  • Destacar la investigación limitada en estas poblaciones e identificar hallazgos únicos relacionados con el envejecimiento/demencia.
  • Proponer un marco para la investigación inclusiva sobre el envejecimiento y la demencia.

Principales métodos:

  • Se realizaron revisiones de literatura utilizando PubMed y Medline para siete trastornos neurológicos/médicos.
  • Se buscaron términos relacionados con trastornos, cognición, neuroimagen, demencia y factores psicosociales.
  • Se excluyeron revisiones, metaanálisis, disertaciones y resúmenes; se centró en variables de investigación primarias.

Principales resultados:

  • La investigación sobre el envejecimiento/demencia en grupos como la esclerosis múltiple y las lesiones cerebrales traumáticas es limitada.
  • La evidencia sugiere un envejecimiento acelerado y un mayor riesgo de demencia en varios trastornos neurológicos/médicos.
  • Existen perfiles cognitivos únicos y la cronicidad afecta los resultados cognitivos; las disparidades en salud se ven exacerbadas.

Conclusiones:

  • Centrarse en las poblaciones neurológicas/médicas en la investigación sobre el envejecimiento/demencia produce información valiosa sobre mecanismos cognitivos, neuronales y psicosociales.
  • La inclusión de estos grupos subrepresentados es esencial para el avance científico en el envejecimiento y la demencia.
  • La investigación futura que incorpore estas poblaciones impulsará el desarrollo de intervenciones efectivas.