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Manifestaciones clínicas

Christian Loveland1, Estevao Ribeiro1, Scott Roye1

  • 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio presenta un caso raro de apraxia del cierre del párpado (AEC) en un paciente con síndrome corticobasal (CBS). Los hallazgos sugieren que la AEC puede ocurrir en condiciones neurodegenerativas como la degeneración corticobasal (CBD), lo que subraya la necesidad de más investigación.

Palabras clave:
apraxia del cierre del párpadosíndrome corticobasaltauopatíaneurodegeneracióndegeneración corticobasal

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Área de la Ciencia:

  • Neurociencia
  • Neurología

Sus antecedentes:

  • Las apraxias palpebrales, incluida la apraxia de la apertura del párpado (AEO) y la más rara apraxia del cierre del párpado (AEC), implican dificultades con los movimientos voluntarios de los párpados.
  • El síndrome corticobasal (CBS) es un trastorno neurodegenerativo progresivo a menudo asociado con tauopatías primarias como la degeneración corticobasal (CBD).
  • Si bien la AEO se reconoce en la CBS, la AEC es menos común y presenta un desafío clínico único.

Objetivo del estudio:

  • Informar un caso de síndrome corticobasal (CBS) que presenta apraxia del cierre del párpado (AEC).
  • Discutir la posible fisiopatología subyacente y los correlatos neuroanatómicos de la AEC en el contexto de la CBS.
  • Contribuir a la comprensión de los trastornos raros del movimiento en enfermedades neurodegenerativas.

Principales métodos:

  • Un informe de caso que detalla a una mujer de 72 años con un historial de 5 años de síntomas neurológicos que incluyen dificultades del habla, parkinsonismo y apraxia.
  • El examen neurológico reveló apraxia del habla y apraxia del cierre del párpado (AEC) con parpadeo reflejo preservado.
  • La resonancia magnética cerebral mostró atrofia bifrontal y del lado derecho leve; el DaT-scan fue negativo.

Principales resultados:

  • La paciente cumplió los criterios de posible síndrome corticobasal (CBS), con una presentación clínica y patrones de atrofia que sugieren una tauopatía 4R, como la degeneración corticobasal (CBD).
  • La apraxia del cierre del párpado (AEC) fue una característica prominente, que ocurrió junto con otros síntomas de CBS.
  • Las pruebas neuropsicológicas indicaron deterioro cognitivo global, con déficits específicos en el control del habla y del movimiento.

Conclusiones:

  • La apraxia del cierre del párpado (AEC) es una condición rara que puede manifestarse en trastornos neurodegenerativos, incluidas las tauopatías primarias como la degeneración corticobasal (CBD).
  • Los hallazgos respaldan la asociación de la AEC con tauopatías 4R y sugieren la posible participación de las redes insular y frontoparietal.
  • Se necesita más investigación para dilucidar la red de lesiones de la AEC y su relación con las redes del lenguaje en enfermedades neurodegenerativas.