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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

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Manifestaciones Clínicas

Michael H Malek-Ahmadi1,2, Angela Kuramoto3, Farah Shaikh3

  • 1Banner Alzheimer's Institute, Phoenix, AZ, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las fluctuaciones en los síntomas de depresión y ansiedad están relacionadas con el deterioro cognitivo en adultos mayores. Comprender la variabilidad afectiva puede ayudar a predecir y mitigar los cambios cognitivos con el tiempo.

Palabras clave:
variabilidad afectivadeterioro cognitivoadultos mayoresdepresiónansiedadestudios longitudinales

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Área de la Ciencia:

  • Neurociencia
  • Gerontología
  • Psiquiatría

Sus antecedentes:

  • Investiga la asociación entre la variabilidad afectiva intraindividual y el declive cognitivo.
  • La investigación previa vincula la depresión y la ansiedad con un menor rendimiento cognitivo en adultos mayores.
  • La mayoría de los estudios son transversales, careciendo de datos longitudinales sobre la variabilidad afectiva y el cambio cognitivo.

Objetivo del estudio:

  • Evaluar si la variabilidad intraindividual en los síntomas de depresión y ansiedad autoinformados predice el deterioro cognitivo.
  • Explorar la relación entre las fluctuaciones de los síntomas afectivos y el rendimiento cognitivo a lo largo del tiempo.
  • Informar estrategias para mitigar el deterioro cognitivo en adultos mayores.

Principales métodos:

  • Estudio longitudinal de 817 adultos de mediana edad y mayores (53-102 años) sin deterioro cognitivo (CU).
  • La cognición se evaluó mediante la Montreal Cognitive Assessment (MoCA).
  • Los síntomas de depresión y ansiedad se midieron utilizando el Center for Epidemiologic Studies Depression 10-Item y el Penn State Worry Questionnaire, respectivamente.
  • La variabilidad se cuantificó mediante la desviación estándar intrasujeto (ISD).

Principales resultados:

  • Una mayor variabilidad en los síntomas de depresión y ansiedad se asoció con un deterioro cognitivo en los análisis primarios.
  • Los análisis exploratorios indicaron que solo la variabilidad de los síntomas depresivos predijo significativamente el deterioro cognitivo.
  • No se encontró ningún efecto de interacción significativo entre la variabilidad de los síntomas depresivos y de ansiedad sobre el deterioro cognitivo.

Conclusiones:

  • La variabilidad dentro del sujeto en los síntomas afectivos se asocia con un declive lineal en el rendimiento cognitivo a lo largo de varios años en adultos mayores CU.
  • La consideración de las fluctuaciones afectivas puede mejorar las estimaciones en estudios observacionales e intervencionistas.
  • Los hallazgos sugieren estrategias potenciales para mitigar el declive cognitivo abordando la variabilidad afectiva.