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Manifestaciones Clínicas

Carrie F Milliard1, Shana G Dodge2, Sweatha Reddy1

  • 1FTD Disorders Registry, King of Prussia, PA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El diagnóstico de la degeneración frontotemporal de variante conductual (bvFTD) es un desafío, y la mayoría de los pacientes experimentan largos retrasos y diagnósticos erróneos. El reconocimiento temprano y la educación del médico son cruciales para un diagnóstico oportuno de bvFTD y mejores resultados para los pacientes.

Palabras clave:
diagnósticobvFTDretrasoerrores de diagnósticosíntomaseducación del médicoresultados del paciente

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Área de la Ciencia:

  • Neurología
  • Neurociencia
  • Psiquiatría

Sus antecedentes:

  • La degeneración frontotemporal de variante conductual (bvFTD) se presenta con cambios conductuales, de personalidad y de función ejecutiva.
  • Los síntomas de bvFTD se superponen con otros trastornos, lo que a menudo conduce a un diagnóstico erróneo y a un tratamiento tardío.
  • Este retraso diagnóstico causa una angustia significativa para los pacientes y sus familias.

Objetivo del estudio:

  • Investigar la trayectoria diagnóstica de las personas con degeneración frontotemporal de variante conductual (bvFTD).
  • Identificar los desafíos, retrasos y tasas de diagnóstico erróneo en la obtención de un diagnóstico de bvFTD.

Principales métodos:

  • Se utilizó el Registro de Trastornos FTD, un registro directo al participante, con una encuesta sobre experiencias diagnósticas.
  • Se recopilaron datos de 50 participantes que especificaron bvFTD como su diagnóstico entre mayo de 2024 y enero de 2025.
  • Se incluyeron en la encuesta a personas diagnosticadas, representantes legalmente autorizados y compañeros de cuidado.

Principales resultados:

  • La mayoría de los encuestados (76%) esperaron más de un año para un diagnóstico de bvFTD, y el 30% experimentó retrasos de 3 a 6 años.
  • Más de la mitad (52%) fueron diagnosticados erróneamente al principio, comúnmente con depresión, ansiedad o deterioro cognitivo leve.
  • Los síntomas angustiantes reportados incluyeron cambios de humor (46%), problemas cognitivos/de juicio (40%) y cambios de personalidad (36%).

Conclusiones:

  • Los retrasos diagnósticos y los diagnósticos erróneos son problemas significativos en la degeneración frontotemporal de variante conductual (bvFTD).
  • Los hallazgos resaltan la necesidad de una mayor educación del médico para reconocer los signos tempranos de bvFTD.
  • Son esenciales vías diagnósticas mejoradas para los pacientes con cambios conductuales, cognitivos o de personalidad inexplicables.