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SHKBP1 es una diana para la sepsis: evidencia del análisis de redes de expresión génica ponderada y múltiples

Fan Wu¹, Junlin Lu¹, Yi Liu¹

¹Department of Emergency Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in immunology

|December 25, 2025

Resumen

Este estudio identifica los genes relacionados con la cuproptosis (CRG) como biomarcadores potenciales de la sepsis. El gen SHKBP1 se destaca como un indicador diagnóstico y pronóstico clave para la sepsis, ofreciendo nuevas dianas terapéuticas.

Área de la Ciencia:

Biología Molecular
Inmunología
Genética

Conclusiones:

Análisis exhaustivo de la expresión de CRG en la sepsis.
Se estableció un modelo diagnóstico novedoso para la sepsis.
Se identificó SHKBP1 como un biomarcador significativo para el diagnóstico y pronóstico de la sepsis, lo que ayuda en el manejo de la sepsis.

Palabras clave:

SHKBP1 genes relacionados con la cuproptosis (CRG)aprendizaje automático sepsis análisis de redes de expresión génica ponderada (WGCNA)

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