Video Experimental Relacionado

Updated: Jan 7, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

Células T CD8 de memoria efectora senescentes con función alterada, enriquecidas en envejecimiento y enfermedad, y

Paolo S Turano¹, Elizabeth Akbulut¹, Nica Mariz Aquino²

¹Rutgers-New Jersey Medical School, Center for Cell Signaling, Department of Microbiology, Biochemistry and Molecular Genetics, 205 South Orange Avenue, Newark, NJ, United States.

bioRxiv : the preprint server for biology

|December 25, 2025

Resumen

Las células T CD8 de memoria efectora (EM) senescentes se acumulan con la edad, mostrando una función alterada y contribuyendo al envejecimiento y la enfermedad. Su estado de senescencia limita la eficacia de la inmunoterapia.

Sus antecedentes:

Las células senescentes son cruciales para la salud, pero su acumulación con la edad altera la homeostasis tisular.
Las células T CD8, vitales para eliminar las células senescentes, también exhiben marcadores de senescencia con el envejecimiento.
Trabajos previos mostraron que las células T CD8 humanas envejecidas desarrollan características de senescencia.

Conclusiones:

El estado de senescencia altera significativamente la función de las células T CD8 T_EM.
Las células T CD8 T_EM senescentes y disfuncionales se implican en el envejecimiento, las enfermedades relacionadas con la edad, la exposición a toxinas y la disminución de la eficacia de la inmunoterapia.

Palabras clave:

senescencia celular células T CD8 memoria efectora envejecimiento inmunoterapia

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