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Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
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Bases estructurales para la formación de fibrillas amiloides del antígeno intracelular 1 de células T reveladas por
Daigo Inaoka1, Tomoko Miyata2,3, Fumiaki Makino2,3,4
1Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto, Kyoto 606-8502, Japan.
PNAS nexus
|December 25, 2025
Resumen
El dominio similar a la prion (PLD) del antígeno intracelular 1 (TIA-1) de las células T forma fibrillas amiloides a través de la separación de fases. La crio-EM revela estructuras lábiles y cómo una mutación G355R interrumpe la formación de fibrillas, ofreciendo información sobre los mecanismos de la enfermedad.
Conclusiones:
- Las estructuras de fibrillas amiloides determinadas del PLD de TIA-1 ofrecen un detalle atómico sin precedentes.
- Estas estructuras revelan características críticas que rigen el ensamblaje y la estabilidad de las fibrillas.
- Los hallazgos proporcionan una base para estudiar los mecanismos moleculares de los trastornos relacionados con TIA-1 y desarrollar estrategias terapéuticas.
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