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Determinación de la Dosis Efectiva de Oliceridina Compuesta con Propofol para Histeroscopia Indolora: Un Estudio

Ke Yang¹, Qian Yuan¹, Hao Huang¹

¹Department of Anesthesiology, Zigong Maternal and Child Health Care Hospital, Zigong, People's Republic of China.

Journal of pain research

|December 25, 2025

Resumen

La dosis efectiva del 95% (DE95) de oliceridina combinada con propofol para histeroscopia indolora se determinó en 1,848 mg. Esta combinación ofrece un enfoque de anestesia intravenosa eficaz para el procedimiento.

Área de la Ciencia:

Anestesiología; Procedimientos Ginecológicos

Sus antecedentes:

La oliceridina combinada con propofol es adecuada para la anestesia intravenosa durante la histeroscopia indolora.

Objetivo del estudio:

Determinar la dosis efectiva del 50% (DE50) y la dosis efectiva del 95% (DE95) de oliceridina cuando se combina con propofol para histeroscopia indolora.

Principales métodos:

Se utilizó el método secuencial modificado de Dixon para ajustar la dosis de oliceridina según la respuesta del paciente.

Principales resultados:

La DE50 de oliceridina fue de 1,583 mg (IC del 95%: 1,444-1,857 mg).
La DE95 de oliceridina fue de 1,848 mg (IC del 95%: 1,701-4,409 mg).

Conclusiones:

Una dosis de 1,848 mg de oliceridina con propofol es eficaz para la anestesia de histeroscopia indolora.

Palabras clave:

DE50 DE95 oliceridina histeroscopia indolora

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