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Manifestaciones Clínicas

Yun Cai1, Rebecca West1, Sharon Sanz Simon1

  • 1Herbert and Jacqueline Krieger Klein Alzheimer's Research Center at Rutgers Brain Health Institute, New Brunswick, NJ, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El reclutamiento de personas del sur de Asia y de Oriente Medio/Norte de África (MENA) para la investigación sobre la enfermedad de Alzheimer y demencias relacionadas (ADRD) presenta desafíos. El estudio SAMENA Cohort tiene como objetivo abordar esta brecha desarrollando estrategias culturalmente adaptadas para una mejor representación en la investigación de ADRD.

Palabras clave:
Alzheimerdemenciareclutamientopoblaciones subrepresentadasestrategias culturalmente adaptadasestudio de cohortesSAMENA Cohortinvestigación de ADRDsur de AsiaMENA

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Área de la Ciencia:

  • Neurociencia; Salud Pública; Genética

Sus antecedentes:

  • Subrepresentación significativa de las poblaciones del sur de Asia y de Oriente Medio/Norte de África (MENA) en la investigación sobre la enfermedad de Alzheimer y demencias relacionadas (ADRD). La evidencia sugiere disparidades en los factores de riesgo, factores protectores y perfiles de biomarcadores de ADRD entre diferentes grupos raciales y étnicos. El estudio SAMENA Cohort tiene como objetivo abordar esta brecha mediante la recopilación de datos longitudinales de descendientes de pacientes con ADRD en estas comunidades subrepresentadas.

Objetivo del estudio:

  • Reclutar participantes de comunidades del sur de Asia y MENA para la investigación de ADRD. Recopilar datos longitudinales integrales sobre los factores de riesgo y protectores de ADRD. Informar el desarrollo de estrategias de prevención y tratamiento adaptadas para estas poblaciones.

Principales métodos:

  • Estrategias de reclutamiento multifacéticas que incluyen alcance comunitario (radio, TV, campamentos de salud), redes sociales, asociaciones con líderes y organizaciones comunitarias, y aprovechamiento de redes universitarias. Colaboración con empresas de reclutamiento para publicidad digital y minería de registros médicos. Cribado e inscripción de participantes en el SAMENA Cohort.

Principales resultados:

  • Durante seis meses, aproximadamente 300 personas contactaron al estudio; el 90% no cumplió los criterios debido a la raza/etnia. Se inscribieron 12 participantes (8 del sur de Asia, 4 MENA), de entre 45 y 64 años, 6 mujeres y 8 con títulos avanzados. Los participantes inscritos mostraron una función cognitiva basal normal (MoCA media=28,4, DE=1,5).

Conclusiones:

  • El reclutamiento inicial enfrentó desafíos significativos para llegar a las poblaciones objetivo del sur de Asia y MENA. Se necesita más investigación para identificar y refinar estrategias de reclutamiento culturalmente adaptadas mediante la participación de diversas partes interesadas. Ampliar los criterios de reclutamiento para incluir a personas con otros factores de riesgo de demencia (por ejemplo, obesidad, diabetes, hipertensión) puede ser beneficioso.