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Manifestaciones Clínicas

Xiaoduo Liu1, Tao Wei1, Yi Tang2,3

  • 1Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los pacientes con enfermedad de Alzheimer (EA) muestran una función glinfática alterada y un acoplamiento de los circuitos oscilatorios del sueño. La precisión reducida del acoplamiento SO-huso en la EA puede impulsar problemas de aclaramiento glinfático y deterioro cognitivo.

Palabras clave:
enfermedad de Alzheimerfunción glinfáticaoscilaciones del sueñodeterioro cognitivoacoplamiento SO-huso

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Área de la Ciencia:

  • Neurociencia
  • Medicina del Sueño
  • Investigación del Sistema Glinfático

Sus antecedentes:

  • Comprender el papel del sueño en el sistema glinfático es crucial para la investigación de la enfermedad de Alzheimer (EA).
  • La disfunción glinfática está implicada en el deterioro cognitivo asociado con la EA.

Objetivo del estudio:

  • Investigar la relación entre los circuitos oscilatorios del sueño y la función del sistema glinfático en la EA.
  • Comparar los índices glinfáticos y el acoplamiento de eventos del sueño entre pacientes con EA y controles sanos.

Principales métodos:

  • 54 pacientes con EA y 21 controles cognitivamente normales (CN) se sometieron a evaluación neuropsicológica, polisomnografía e imágenes multimodales.
  • Se analizaron eventos oscilatorios del sueño (SOs, ráfagas theta, husos de sueño) y su acoplamiento.
  • Se midieron y compararon los índices glinfáticos (volumen CP, PVS, acoplamiento DTI-ALPS, BOLD-CSF).

Principales resultados:

  • Los pacientes con EA exhibieron una peor función glinfática y una menor precisión en el acoplamiento SO-huso. Se encontraron diferencias significativas en el volumen del CP, DTI-ALPS, acoplamiento BOLD-CSF y fase SO entre los grupos. DTI-ALPS medió la asociación entre la fase SO y los cambios cognitivos/biomarcadores, destacando el papel del sueño en la función glinfática.

Conclusiones:

  • Los circuitos oscilatorios del sueño y el sistema glinfático interactúan, y esta interacción está disminuida en la EA.
  • La precisión reducida del acoplamiento SO-huso en la EA puede perjudicar el aclaramiento glinfático, contribuyendo al deterioro cognitivo.