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Manifestaciones Clínicas

Camila Rafaela Lazaretti1, Cristiano Aguzzoli1

  • 1Feevale University, Novo Hamburgo, RS, Brazil.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La COVID-19 puede causar déficits cognitivos duraderos, afectando la memoria y las funciones ejecutivas en más de la mitad de los supervivientes, independientemente de la gravedad de los síntomas. El seguimiento a largo plazo es crucial para evaluar la función cognitiva después de la infección.

Palabras clave:
COVID-19Deterioro cognitivoFunción ejecutivaMemoriaSARS-CoV-2

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Área de la Ciencia:

  • Neurología
  • Enfermedades Infecciosas
  • Ciencia Cognitiva

Sus antecedentes:

  • La COVID-19 afecta significativamente las funciones cognitivas, incluidas las habilidades corticales superiores.
  • Los déficits cognitivos prolongados se reconocen cada vez más después de la infección por SARS-CoV-2.
  • Esta revisión compara el deterioro cognitivo a largo plazo entre casos de COVID-19 de leve a moderada y graves.

Objetivo del estudio:

  • Revisar y comparar el deterioro cognitivo a largo plazo en individuos con diversas gravidades de COVID-19.
  • Identificar los dominios cognitivos más afectados por la COVID-19 a largo plazo.
  • Destacar la persistencia de los déficits cognitivos después de la recuperación.

Principales métodos:

  • Una revisión de alcance de artículos indexados en PubMed de 2020 a 2024.
  • Inclusión de estudios que evalúan el deterioro cognitivo a largo plazo en supervivientes de COVID-19.
  • Cribado de veinte artículos, con ocho publicaciones a texto completo evaluadas.

Principales resultados:

  • La prevalencia del deterioro cognitivo varió del 61,5 % (leve-moderado) al 80 % (moderado-grave) en la fase aguda.
  • Las funciones ejecutivas, la memoria de trabajo, la fluidez verbal y la atención fueron las más afectadas.
  • Más del 50 % experimentó déficits a largo plazo en la atención, la memoria y la función ejecutiva; los casos graves mostraron problemas persistentes meses después del alta.

Conclusiones:

  • El deterioro cognitivo post-COVID-19 afecta a una proporción significativa de supervivientes en todas las etapas clínicas.
  • El deterioro de la memoria es el déficit cognitivo a largo plazo predominante observado.
  • La evaluación clínica y el seguimiento a largo plazo centrado en la función cognitiva son esenciales para los supervivientes de COVID-19.