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Desarrollo de Fármacos

Emily A Largent1, Josh D Grill2, Jason Karlawish3

  • 1University of Pennsylvania, Philadelphia, PA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El requisito de un compañero de estudio en los ensayos de prevención de la enfermedad de Alzheimer puede dificultar el reclutamiento. Sin embargo, la subrepresentación de adultos mayores negros no se debe a menores intenciones de participación, lo que sugiere que existen otras barreras.

Palabras clave:
Alzheimerensayos clínicosreclutamientobarrerasdisparidades raciales

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Área de la Ciencia:

  • Neurociencia
  • Ensayos Clínicos
  • Salud Pública

Sus antecedentes:

  • El reclutamiento de muestras representativas para ensayos de prevención secundaria de la enfermedad de Alzheimer es crucial para un tratamiento eficaz.
  • Investigaciones anteriores indican que el requisito de 'compañero de estudio' puede afectar desproporcionadamente la inscripción de grupos raciales y étnicos subrepresentados.

Objetivo del estudio:

  • Evaluar el impacto del requisito de compañero de estudio en las intenciones de inscripción en ensayos de prevención secundaria.
  • Investigar las posibles disparidades raciales y étnicas en la participación y las intenciones de reclutamiento de compañeros de estudio.

Principales métodos:

  • Se realizó una encuesta nacional a adultos estadounidenses de 65 años o más, con un sobremuestreo de personas negras.
  • Los participantes indicaron su intención de inscribirse en un ensayo hipotético y de pedir a alguien que fuera compañero de estudio.
  • Se utilizaron estadísticas descriptivas y cálculos de diferencias para analizar las intenciones de inscripción y de compañero de estudio.

Principales resultados:

  • La intención de inscribirse en el Estudio HEALTHY MIND fue generalmente baja (24% de los encuestados).
  • Entre los que tenían la intención de inscribirse, la intención de pedir un compañero de estudio fue moderada (puntuación media 3,45).
  • No se encontraron diferencias significativas entre los encuestados negros y blancos en su intención de inscribirse o pedir un compañero de estudio.

Conclusiones:

  • El requisito de compañero de estudio parece ser una barrera para el reclutamiento en ensayos de prevención secundaria.
  • La subrepresentación de adultos mayores negros no se explica por menores intenciones de participación o de compañero de estudio.
  • Otros factores, como criterios de inclusión restrictivos o barreras estructurales, probablemente contribuyen a la falta de representación.