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Manifestaciones Clínicas

Abbie Palmer1, Millie Sander1, Clive G Ballard1

  • 1University of Exeter, Exeter, United Kingdom.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El Covid prolongado puede causar un deterioro cognitivo significativo, afectando particularmente la memoria y la función ejecutiva. Los factores del estilo de vida se asocian con estos déficits, lo que subraya la necesidad de una orientación clínica específica.

Palabras clave:
Covid prolongadodeterioro cognitivofunción ejecutivamemoriaestilo de vidaorientación clínica

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Área de la Ciencia:

  • Neurociencia
  • Salud Pública
  • Ciencia Cognitiva

Sus antecedentes:

  • El Covid prolongado afecta al menos al 9,9% de las personas, con síntomas neuropsiquiátricos como el deterioro cognitivo que afectan a más del 25% de los pacientes.
  • Los déficits cognitivos en el Covid prolongado afectan significativamente la calidad de vida, el empleo y las actividades sociales.
  • La etiología de los síntomas cognitivos del Covid prolongado se comprende mal, lo que requiere más investigación.

Objetivo del estudio:

  • Caracterizar el perfil cognitivo de las personas con Covid prolongado.
  • Comparar el rendimiento cognitivo en pacientes con Covid prolongado con una cohorte sana de edad comparable.
  • Identificar los factores asociados con el deterioro cognitivo en el Covid prolongado.

Principales métodos:

  • Se reclutaron 2185 participantes con deterioro cognitivo subjetivo post-Covid-19 para el ensayo BEACON.
  • Se administraron cuestionarios demográficos, de salud, de salud mental, de fatiga y de bienestar.
  • Se utilizó el sistema de pruebas cognitivas FLAME para evaluar la memoria, la atención y la función ejecutiva; análisis comparativo con datos de la cohorte PROTECT-UK.

Principales resultados:

  • La cohorte BEACON presentó un perfil de deterioro cognitivo único en comparación con los controles sanos.
  • Se observó un deterioro marcado en la memoria y la función ejecutiva, particularmente en aquellos con antecedentes de Covid-19 grave.
  • Los análisis de regresión identificaron asociaciones entre los factores del estilo de vida y el deterioro cognitivo.

Conclusiones:

  • Proporciona una caracterización cognitiva detallada de los pacientes con Covid prolongado, revelando trayectorias cognitivas potencialmente únicas.
  • Destaca la importancia de la orientación clínica para detectar, monitorizar y tratar el deterioro cognitivo en el Covid prolongado.
  • Enfatiza la necesidad de una mayor investigación sobre los mecanismos subyacentes y las intervenciones eficaces para la disfunción cognitiva del Covid prolongado.