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Manifestaciones Clínicas

Catherine Bikeri Onyancha1, Benard O Aliwa2, Jasmit Shah3

  • 1Brain and Mind Institute, Aga Khan University, Nairobi, Kenya.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El malestar psicológico y las preocupaciones cognitivas subjetivas están relacionados con marcadores clínicos de salud en adultos africanos. Los factores demográficos como la edad y el género pueden influir en estas asociaciones de riesgo de demencia.

Palabras clave:
malestar psicológicopreocupaciones cognitivas subjetivasmarcadores de saludadultos africanosprevención de la demenciafactores demográficosedadgéneroriesgo de demencia

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Área de la Ciencia:

  • Neurociencia; Salud Pública; Gerontología

Sus antecedentes:

  • El malestar psicológico es un factor de riesgo conocido para la demencia, que afecta los procesos de envejecimiento. Las preocupaciones cognitivas subjetivas (SCC) son indicadores tempranos de riesgo de demencia. Comprender estos vínculos en las poblaciones africanas es vital para intervenciones culturalmente relevantes.

Objetivo del estudio:

  • Investigar las asociaciones entre el malestar psicológico, las SCC y los marcadores clínicos de salud en adultos africanos. Explorar el papel de los factores demográficos en estas relaciones.

Principales métodos:

  • Análisis de datos de referencia de 145 adultos (≥35 años) del estudio Brain Resilience Kenya. Evaluación del malestar psicológico (PHQ-9, GAD-7) y las SCC mediante autoinforme. Medición de biomarcadores clínicos que incluyen glucosa, lípidos, creatinina, función hepática y tiroidea.

Principales resultados:

  • Los síntomas depresivos se correlacionaron con la relación colesterol/HDL y el colesterol no HDL. Las SCC se relacionaron con síntomas depresivos, creatinina y niveles de AST. Las asociaciones entre las SCC y los marcadores clínicos disminuyeron después de ajustar por edad y género.

Conclusiones:

  • Se debe abordar la salud mental en las estrategias de prevención de la demencia. Los factores demográficos influyen significativamente en la relación entre el malestar psicológico, las SCC y los marcadores clínicos. Se necesita más investigación longitudinal para comprender el riesgo de demencia y desarrollar intervenciones específicas para las poblaciones africanas.