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Manifestaciones Clínicas

Nav Vij1, Jermyn Z See1, See Ann Soo1

  • 1Neurowyzr Pte Ltd, Singapore, Singapore, Singapore.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La detección temprana del deterioro cognitivo leve (DCL) es posible con la detección digital. Los cambios en el estilo de vida, como el ejercicio y el control de la diabetes, pueden reducir significativamente el riesgo de DCL y los costos de la demencia.

Palabras clave:
deterioro cognitivo levedetección digitalfactores de riesgocambios en el estilo de vidaprevención de la demencia

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Área de la Ciencia:

  • Neurología; Gerontología; Salud Pública

Sus antecedentes:

  • El deterioro cognitivo leve (DCL) es una etapa crítica entre el envejecimiento normal y la demencia, lo que presenta una oportunidad para la intervención temprana.; La demencia representa una carga económica global significativa, con costos proyectados que superan los 2 billones de dólares estadounidenses para 2030.; En Singapur, la demencia afecta a aproximadamente el 10% de las personas mayores, lo que genera importantes costos de atención médica.

Objetivo del estudio:

  • Evaluar la efectividad de la Detección Digital de la Función Cerebral (DBFS) de Neurowyzr en la identificación de signos tempranos de DCL.; Identificar factores de riesgo de estilo de vida modificables asociados con el DCL en una población de Singapur.; Explorar el potencial de las herramientas digitales para la detección temprana y las estrategias de prevención del DCL.

Principales métodos:

  • El DBFS, una herramienta digital de grado médico, evaluó la función cognitiva en atención, función ejecutiva, memoria inmediata y memoria de trabajo.; Un cuestionario de estilo de vida recopiló datos sobre actividad física, sueño, nutrición, uso de sustancias, condiciones médicas y estimulación cognitiva.; Se aplicó modelado estadístico a datos del mundo real de más de 2000 personas evaluadas en Singapur para identificar factores de riesgo de DCL.

Principales resultados:

  • La función cognitiva disminuyó con el aumento de la edad, identificándose la diabetes, el tabaquismo y la ingesta elevada de azúcar como factores de riesgo significativos de DCL.; La actividad física regular, en particular el entrenamiento cardiovascular y de resistencia, demostró efectos neuroprotectores.; Niveles más altos de educación y la participación en actividades cognitivamente estimulantes se asociaron con una menor probabilidad de declive cognitivo.

Conclusiones:

  • Los datos del mundo real confirman la naturaleza multifactorial del DCL y resaltan factores de riesgo modificables clave.; El DBFS es una herramienta escalable prometedora para la detección temprana del DCL y facilita la prevención dirigida.; Las intervenciones centradas en el manejo de la diabetes, la cesación del tabaquismo, la reducción de la ingesta de azúcar, el ejercicio, la educación y la estimulación cognitiva pueden mitigar el riesgo de DCL y reducir el impacto económico de la demencia.