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Desarrollo de Fármacos

Guillaume Blivet1, Hugo Cavadore2, Marwan N Sabbagh3

  • 1REGEnLIFE, Montpellier, France.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La fotobiomodulación (PBM) es un tratamiento seguro y no invasivo que muestra resultados prometedores para la enfermedad de Alzheimer (EA). Se necesitan más estudios de alta calidad para confirmar su eficacia y establecer protocolos estandarizados para uso clínico.

Palabras clave:
fotobiomodulaciónenfermedad de Alzheimerterapia con luzneurocienciaingeniería biomédicagerontología

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Área de la Ciencia:

  • Neurociencia; Ingeniería Biomédica; Gerontología

Sus antecedentes:

  • La patofisiología de la enfermedad de Alzheimer (EA) implica proteinopatía, estrés oxidativo, neuroinflamación y disbiosis del eje intestino-cerebro.; La fotobiomodulación (PBM) utiliza la terapia con luz de baja intensidad como tratamiento no invasivo para la EA.; Los estudios preclínicos de PBM sugieren que reduce el estrés oxidativo, la inflamación y mejora la neurogénesis.

Objetivo del estudio:

  • Evaluar críticamente la evidencia clínica actual sobre la terapia PBM para la EA.; Evaluar el potencial terapéutico y la viabilidad de la PBM para el tratamiento de la EA.; Explorar el papel de la PBM en estrategias de tratamiento combinado para la EA.

Principales métodos:

  • Revisión sistemática de ocho estudios clínicos publicados desde 2017.; Se incluyeron ensayos controlados aleatorizados (ECA) doble ciego, simple ciego y abiertos.; Los estudios involucraron a pacientes con EA, demencia o deterioro cognitivo leve (DCL).

Principales resultados:

  • La PBM se demuestra consistentemente como segura para la EA y demencias relacionadas.; La evidencia preliminar sugiere beneficios cognitivos potenciales de la terapia PBM.; La evidencia limitada debido a tamaños de muestra pequeños y heterogeneidad metodológica requiere más investigación.

Conclusiones:

  • La terapia PBM tiene una promesa significativa como tratamiento no invasivo y seguro para la EA.; La aplicación clínica generalizada requiere una validación rigurosa de la eficacia y protocolos estandarizados.; Futuros estudios de alta calidad son cruciales para establecer la PBM como una opción terapéutica convencional para la EA.