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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Manifestaciones Clínicas
Esther Brill1, Alexa Frederike Holfelder1, Michael Falkner2
1University Hospital of Old Age Psychiatry and Psychotherapy, Bern, Bern, Switzerland.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
Resumen
El entrenamiento cognitivo computarizado (CCT) no mostró beneficios a corto plazo para el deterioro cognitivo en adultos mayores. La alta adherencia sugiere que el CCT puede ser valioso a largo plazo o en combinación con otras intervenciones.
Área de la Ciencia:
- Neurociencia; Gerontología; Psicología Cognitiva
Sus antecedentes:
- El deterioro cognitivo subjetivo (SCD) y el deterioro cognitivo leve (MCI) predicen la enfermedad de Alzheimer.; El entrenamiento cognitivo computarizado (CCT) es una intervención no farmacológica potencial.; Estudios previos de CCT muestran resultados mixtos y desafíos de adherencia.
Objetivo del estudio:
- Evaluar la efectividad del CCT en personas con SCD/MCI.; Comparar el CCT con grupos de control activo y de lista de espera.; Evaluar biomarcadores neurofisiológicos y basados en sangre.
Principales métodos:
- Ensayo controlado aleatorizado (ECA) bicéntrico con 155 participantes (edad media 72.2).; Tres brazos: CCT, control activo (documentales), control de lista de espera.; Intervención de tres meses con 60 sesiones, seguida de 6 meses de CCT para el grupo de intervención.
Principales resultados:
- No hubo una interacción significativa entre grupos y momentos en cuanto a los resultados cognitivos.; Se observó una alta adherencia (4.87 sesiones/semana) en todos los grupos.; No se observaron cambios en el volumen de materia gris ni en los niveles de amiloide; se notaron mejoras subjetivas después del entrenamiento a largo plazo.
Conclusiones:
- El CCT de tres meses no mostró ventajas cognitivas o biológicas específicas.; La alta adherencia indica la importancia de intervenciones personalizadas y relevantes.; El CCT a largo plazo mostró efectos subjetivos positivos, lo que sugiere su papel en intervenciones multicomponentes.
Palabras clave:
entrenamiento cognitivo computarizadodeterioro cognitivoadultos mayoresenvejecimiento saludableAlzheimerMás Videos Relacionados
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