Video Experimental Relacionado

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Desarrollo de Fármacos

Benoit Delatour¹, Susana Boluda², Alexandre Carpentier³

¹Paris Brain Institute (ICM), Inserm, CNRS, Sorbonne University, Paris, Ile de France, France.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

Resumen

La apertura transitoria de la barrera hematoencefálica mediante ultrasonidos mitigó la propagación de lesiones tau en un modelo murino de la enfermedad de Alzheimer. Este enfoque muestra potencial para el tratamiento de tauropatías como la enfermedad de Alzheimer y la demencia frontotemporal.

Área de la Ciencia:

Neurociencia
Neuropatología

Sus antecedentes:

Las tauropatías están relacionadas con mutaciones en el gen MAPT.
La apertura transitoria de la barrera hematoencefálica mediada por ultrasonidos ha mostrado potencial en la mitigación de tauropatías.

Objetivo del estudio:

Evaluar el efecto de la sonicación en la propagación de lesiones tau de tipo priónico.
Investigar las aplicaciones terapéuticas de la apertura de la barrera hematoencefálica para las tauropatías.

Principales métodos:

Se inocularon ratones P301S con extractos cerebrales de Alzheimer o extractos de control.
Los ratones recibieron aperturas transitorias repetidas de la barrera hematoencefálica mediante sonicación durante seis semanas.
Se realizaron análisis neuropatológicos post-sacrificio.

Principales resultados:

La sonicación no alteró las tauropatías intrínsecas en ratones de control.
La sonicación repetida mitigó significativamente la propagación de las lesiones tau desde el hipocampo a otras regiones cerebrales en ratones modelo de Alzheimer.
Se están investigando mecanismos que incluyen la respuesta de la microglía y la modulación de la autofagia.

Conclusiones:

La apertura transitoria repetida de la barrera hematoencefálica reduce eficazmente la propagación acelerada de lesiones tau.
Este método sugiere estrategias terapéuticas potenciales para la enfermedad de Alzheimer y la demencia frontotemporal.

Palabras clave:

ultrasonido barrera hematoencefálica tauropatías enfermedad de Alzheimer demencia frontotemporal

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