Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

In Vitro Drug Release Testing: Overview, Development and Validation

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...

Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Clinical responses to trastuzumab deruxtecan in molecularly defined ependymoma.

NPJ precision oncology·2026

Same author

Development of skull-implanted ultrasound for blood-brain barrier opening and drug delivery in neuro-oncology.

Neuro-oncology advances·2026

Same author

Does neurodevelopmental load predict cognitive flexibility?

Schizophrenia research. Cognition·2026

Same author

Development and preclinical evaluation of a hybrid stereoelectroencephalographic-laser depth electrode for magnetic resonance imaging-guided interstitial thermal therapy in drug-resistant epilepsy.

Epilepsia·2026

Same author

One Health Investigation into Fatal Encephalitis Caused by Pigeon Paramyxovirus Type 1, France.

Emerging infectious diseases·2026

Same author

Outpatient supratentorial craniotomy for brain lesions: a pilot feasibility and safety study.

Neurosurgical review·2026

Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Ver todos los artículos relacionados

Search research articles

Video Experimental Relacionado

Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Desarrollo de Fármacos

Benoit Delatour¹, Susana Boluda², Alexandre Carpentier³

¹Paris Brain Institute (ICM), Inserm, CNRS, Sorbonne University, Paris, Ile de France, France.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

Resumen

Este resumen es generado por máquina.

La apertura transitoria de la barrera hematoencefálica mediante ultrasonidos mitigó la propagación de lesiones tau en un modelo murino de la enfermedad de Alzheimer. Este enfoque muestra potencial para el tratamiento de tauropatías como la enfermedad de Alzheimer y la demencia frontotemporal.

Palabras clave:

ultrasonido barrera hematoencefálica tauropatías enfermedad de Alzheimer demencia frontotemporal

Más Videos Relacionados

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

In Vitro Three-Dimensional Sprouting Assay of Angiogenesis Using Mouse Embryonic Stem Cells for Vascular Disease Modeling and Drug Testing

Published on: May 11, 2021

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

Published on: October 10, 2025

Área de la Ciencia:

Neurociencia
Neuropatología

Sus antecedentes:

Las tauropatías están relacionadas con mutaciones en el gen MAPT.
La apertura transitoria de la barrera hematoencefálica mediada por ultrasonidos ha mostrado potencial en la mitigación de tauropatías.

Objetivo del estudio:

Evaluar el efecto de la sonicación en la propagación de lesiones tau de tipo priónico.
Investigar las aplicaciones terapéuticas de la apertura de la barrera hematoencefálica para las tauropatías.

Principales métodos:

Se inocularon ratones P301S con extractos cerebrales de Alzheimer o extractos de control.
Los ratones recibieron aperturas transitorias repetidas de la barrera hematoencefálica mediante sonicación durante seis semanas.
Se realizaron análisis neuropatológicos post-sacrificio.

Principales resultados:

La sonicación no alteró las tauropatías intrínsecas en ratones de control.
La sonicación repetida mitigó significativamente la propagación de las lesiones tau desde el hipocampo a otras regiones cerebrales en ratones modelo de Alzheimer.
Se están investigando mecanismos que incluyen la respuesta de la microglía y la modulación de la autofagia.

Conclusiones:

La apertura transitoria repetida de la barrera hematoencefálica reduce eficazmente la propagación acelerada de lesiones tau.
Este método sugiere estrategias terapéuticas potenciales para la enfermedad de Alzheimer y la demencia frontotemporal.