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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarcadores

Heidi Espedal1, Dona M P Jayakody2,3, Adriano Polpo2

  • 1The University of Western Australia, Western Australia National Imaging Facility, Perth, Western Australia, Australia.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La intervención temprana con audífonos en adultos mayores con deterioro cognitivo mostró una mejoría del metabolismo cerebral en áreas motoras. Esto sugiere beneficios potenciales del apoyo auditivo oportuno para la salud cerebral.

Palabras clave:
metabolismo cerebralaudífonosdeterioro cognitivoadultos mayoresensayo clínico

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Área de la Ciencia:

  • Neuroscience
  • Radiology
  • Gerontology

Sus antecedentes:

  • The HearCog trial investigated hearing aid effects on age-related hearing loss and cognitive impairment.
  • A substudy used 18F-FDG PET/CT to assess brain metabolism changes after early versus delayed hearing aid intervention.

Objetivo del estudio:

  • To evaluate brain metabolic activity patterns using 18F-FDG PET/CT.
  • To compare metabolic changes between early (Group A) and delayed (Group B) hearing aid intervention groups.

Principales métodos:

  • 28 participants (mean age 77.4 years) underwent baseline and 12-month 18F-FDG PET/CT scans.
  • Analysis involved co-registration with a healthy volunteer database (n=33) and automated brain region labeling.
  • Statistical testing compared group differences and database comparisons at both timepoints.

Principales resultados:

  • No significant baseline differences between groups in demographics or imaging parameters.
  • Early intervention (Group A) showed increased 18F-FDG uptake in 5 brain regions compared to delayed intervention (Group B) at 12 months.
  • Affected regions included central, left central, right rolandic operculum, left paracentral lobule, and left precentral gyrus.

Conclusiones:

  • Standardized analysis indicates relative improvements in motor/sensorimotor brain areas with early hearing aid intervention.
  • Further research integrating MRI and PET data is planned for detailed evaluation of cognitive and auditory regions.