Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Infection01:20

Infection

11.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

521
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
521
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

674
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
674
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
Stages of Infection01:26

Stages of Infection

64.7K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
64.7K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.6K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Lymphocyte-Platelet and Neutrophil-Platelet Aggregates are Associated with Dysregulated Platelet Inflammatory Pathways in Psoriasis.

Journal of psoriasis and psoriatic arthritis·2026
Same author

Whole blood epigenomic and transcriptomic characterization identifies vulnerable molecular subtypes of chronic coronary disease.

Nature communications·2026
Same author

Validation of Brachial Vein Endothelial Transcriptomics to Assess the Coronary Vasculature.

Circulation research·2026
Same author

Bleeding history is associated with lower risk of cardiovascular events in a cohort undergoing lower extremity revascularization.

Journal of thrombosis and thrombolysis·2026
Same author

Precision Antiplatelet Therapy: The Promise and Complexity of Pharmacogenomic Antiplatelet Therapy.

Circulation. Cardiovascular interventions·2026
Same author

Melanocortin receptor 4 agonist setmelanotide treats opioid-induced respiratory depression.

bioRxiv : the preprint server for biology·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K

Ciencia básica y patogénesis

Tovia Jacobs1, Jaime Ramos Cejudo1, Mark He2

  • 1NYU Grossman School of Medicine, New York, NY, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La agregación plaquetaria elevada se relaciona con un aumento de los marcadores de patología de la enfermedad de Alzheimer (EA) como p-tau181 y el marcador de neurodegeneración NfL en pacientes con enfermedad arterial periférica (EAP). Se necesita más investigación para confirmar estos hallazgos en cohortes más grandes.

Palabras clave:
agregación plaquetariaenfermedad de Alzheimerbiomarcadoresenfermedad arterial periféricatauneurofilamentos

Más Videos Relacionados

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
09:07

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses

Published on: June 14, 2020

11.5K
A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia
13:45

A Precise Pathogen Delivery and Recovery System for Murine Models of Secondary Bacterial Pneumonia

Published on: September 21, 2019

6.0K
Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
08:38

Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

6.3K

Área de la Ciencia:

  • Neurología; Medicina Cardiovascular; Bioquímica

Sus antecedentes:

  • Los factores de riesgo cardiovascular contribuyen significativamente a la demencia, pero los mecanismos biológicos subyacentes requieren aclaración.; La agregación plaquetaria elevada es un factor de riesgo conocido para la demencia, complicado por comorbilidades en individuos con alta carga vascular.; El estudio de Actividad Plaquetaria y Eventos Cardiovasculares (PACE) investigó el vínculo entre la actividad plaquetaria y los biomarcadores de la enfermedad de Alzheimer (EA) en pacientes con enfermedad arterial periférica (EAP).

Objetivo del estudio:

  • Aclarar los mediadores biológicos que vinculan los factores de riesgo cardiovascular con la demencia.; Examinar la relación entre la agregación plaquetaria y los biomarcadores de la EA en pacientes con EAP.; Investigar las posibles asociaciones entre la actividad plaquetaria y los marcadores de patología de la EA y neurodegeneración.

Principales métodos:

  • La agregación plaquetaria se midió mediante agregometría de transmisión de luz (LTA).; Las concentraciones séricas de tau fosforilada (p-tau181), tau total, neurofilamento ligero (NfL) y proteína quinasa C (GFAP) se cuantificaron mediante SIMOA.; Se utilizaron modelos de regresión cuantil para evaluar las asociaciones, con ajustes para covariables univariadas seleccionadas por LASSO y factores demográficos/de tratamiento.

Principales resultados:

  • En 101 pacientes con EAP, la agregación plaquetaria elevada (con ADP y Epinefrina) se correlacionó con niveles elevados de p-tau181 y NfL.; No se encontraron asociaciones significativas entre la agregación plaquetaria y los niveles de tau total o GFAP.; La cohorte del estudio tuvo una edad media de 70 años, siendo la mayoría hombres, con enfermedad polivascular y en tratamiento antiplaquetario.

Conclusiones:

  • La agregación plaquetaria se asocia con marcadores de patología de la EA (p-tau181) y neurodegeneración (NfL) en pacientes con EAP sin demencia.; Estos hallazgos sugieren un papel potencial de la agregación plaquetaria en la mediación de la patología de la EA y la neuroinflamación.; Son necesarios estudios de cohortes más amplios para validar estas asociaciones y explorar los mecanismos subyacentes.