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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

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Manifestaciones Clínicas

Rachel Membreno1, Carlos E E Araujo Menendez2, Ariana M Stickel1

  • 1San Diego State University, San Diego, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los portadores de APOE ε4 mostraron una mejor preservación de la materia gris de la corteza entorrinal derecha con la edad en comparación con los no portadores en adultos hispanos/latinos. Esto sugiere un efecto protector del APOE ε4 en esta población con respecto al envejecimiento cerebral.

Palabras clave:
envejecimiento cerebralAPOE ε4corteza entorrinaladultos hispanos/latinosestructura cerebral

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Área de la Ciencia:

  • Neurociencia; Genética; Gerontología

Sus antecedentes:

  • La apolipoproteína E4 (APOE ε4) es un factor de riesgo genético conocido para la enfermedad de Alzheimer (EA).; El impacto del APOE ε4 en el envejecimiento cerebral puede variar entre grupos raciales y étnicos, particularmente en poblaciones desatendidas como los adultos hispanos/latinos.; Comprender estas variaciones es crucial para estrategias específicas de prevención y tratamiento de la EA.

Objetivo del estudio:

  • Investigar la interacción entre el estado de APOE ε4 y la edad en los volúmenes del hipocampo y la corteza entorrinal en adultos hispanos/latinos.; Determinar si el APOE ε4 influye en los cambios de la estructura cerebral relacionados con la edad en este grupo demográfico específico.; Explorar los posibles efectos protectores o perjudiciales del APOE ε4 en las estructuras del lóbulo temporal medial.

Principales métodos:

  • Análisis de datos de 187 adultos hispanos/latinos (edades 53-94) de la base de datos del National Alzheimer's Coordinating Center.; Se examinó la interacción entre el estado de portador de APOE ε4 y la edad (continua) en los volúmenes de materia gris del hipocampo y la corteza entorrinal.; Se utilizaron modelos lineales generales, ajustando por sexo, para evaluar el impacto en los volúmenes cerebrales del lóbulo temporal medial.

Principales resultados:

  • Se encontró una interacción significativa entre el estado de APOE ε4 y la edad en el volumen de materia gris de la corteza entorrinal derecha (p=0.011).; La edad avanzada se asoció con una reducción del volumen de materia gris de la corteza entorrinal derecha en no portadores de APOE ε4.; No se observó una asociación significativa entre la edad y el volumen en portadores de APOE ε4, lo que sugiere una posible preservación.

Conclusiones:

  • Los hallazgos sugieren que los portadores de APOE ε4 pueden experimentar una mejor preservación del volumen de materia gris de la corteza entorrinal derecha en la edad avanzada en comparación con los no portadores dentro de la población hispana/latina.; La ascendencia genética puede desempeñar un papel en la modulación de la relación entre el APOE ε4 y el envejecimiento cognitivo en adultos hispanos/latinos.; Se recomienda una mayor investigación sobre la ascendencia genética y otros factores genéticos para comprender completamente el riesgo y la protección de la EA en este grupo.