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Manifestaciones Clínicas

Micaela Mitolo1,2, Davide Braghittoni3, Greta Venturi3

  • 1University of Parma, Parma, Italy, Italy.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los pacientes con Demencia con Cuerpos de Lewy (DCL) muestran déficits de atención y un peor rendimiento en tareas de atención sostenida. La reducida actividad cerebral en el cuneus y precuneus se relaciona con tiempos de reacción más lentos en pacientes con DCL.

Palabras clave:
Demencia con Cuerpos de Lewyatenciónresonancia magnética funcionalneuropsicologíacuneusprecuneus

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Área de la Ciencia:

  • Neurociencia; Neurología; Ciencias Cognitivas

Sus antecedentes:

  • La Demencia con Cuerpos de Lewy (DCL) se caracteriza por déficits de atención.; La comprensión de la actividad cerebral funcional durante las tareas de atención es crucial para la investigación de la DCL.

Objetivo del estudio:

  • Comparar la actividad cerebral funcional durante una tarea de atención sostenida entre pacientes con DCL y controles sanos.; Identificar regiones y redes cerebrales específicas afectadas en DCL durante tareas de atención.

Principales métodos:

  • Estudio de fMRI que involucró a 20 pacientes con DCL y 20 controles sanos (CS).; Se utilizó la Tarea de Vigilancia Psicomotora Auditiva (PVT) para evaluar la atención sostenida.; Evaluaciones neuropsicológicas y análisis de datos de resonancia magnética cerebral con fMRI.

Principales resultados:

  • Los pacientes con DCL exhibieron un peor rendimiento en pruebas de atención visuoespacial y sostenida (PVT).; Reducción significativa de la activación cerebral en pacientes con DCL en comparación con controles sanos (CS) en la corteza occipital lateral superior derecha, cuneus y precuneus durante la PVT.; Los tiempos de reacción más lentos en DCL se correlacionaron con una menor activación en el cuneus y precuneus.

Conclusiones:

  • Los pacientes con DCL demuestran déficits en los dominios de atención y visuoespacial.; El cuneus y el precuneus desempeñan un papel crítico en la atención sostenida, con una actividad reducida relacionada con déficits cognitivos en DCL.; Se necesita más investigación con cohortes de DCL más grandes para dilucidar los mecanismos funcionales de los déficits de atención.