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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

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Manifestaciones Clínicas

Rachel N Schade1, Andrew O'Shea2, Katie Rodriguez1

  • 1University of Florida, Gainesville, FL, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los adultos mayores preocupados por quejas cognitivas subjetivas (SCC) muestran un peor rendimiento en tareas de memoria espacial, potencialmente relacionado con el estado de ánimo y la motivación en lugar de cambios en el hipocampo. Esto sugiere que la preocupación puede indicar la enfermedad de Alzheimer (EA) preclínica temprana.

Palabras clave:
quejas cognitivas subjetivaspreocupaciónmemoria espacialenfermedad de Alzheimer preclínicaestado de ánimomotivación

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Área de la Ciencia:

  • Neurociencia
  • Psicología Cognitiva
  • Gerontología

Sus antecedentes:

  • Las quejas cognitivas subjetivas (SCC) se asocian con cambios en el hipocampo y un mayor riesgo de enfermedad de Alzheimer (EA) preclínica.
  • Los individuos con SCC que experimentan angustia (; preocupados;) pueden representar un subgrupo distinto con mayor riesgo.
  • Este estudio investigó las diferencias entre individuos preocupados y no preocupados con SCC.

Objetivo del estudio:

  • Comparar el rendimiento y la volumetría de las tareas del hipocampo entre individuos preocupados y no preocupados con SCC.
  • Determinar si el estado de ánimo y/o la motivación influyen en el rendimiento cognitivo en estos grupos.
  • Explorar posibles vínculos entre la preocupación por SCC y los indicadores preclínicos de EA.

Principales métodos:

  • 154 adultos con SCC se dividieron en grupos "preocupados" (N=76) y "no preocupados" (N=78).
  • Las evaluaciones cognitivas incluyeron tareas basadas en el hipocampo (ARENA, MST).
  • El estado de ánimo (BDI-II, AS, STAI) y la volumetría del hipocampo se analizaron mediante ANCOVA y pruebas t.

Principales resultados:

  • El grupo preocupado tuvo un rendimiento significativamente peor en las tareas de navegación espacial (ARENA) pero no en la separación de patrones (MST).
  • No se encontraron diferencias significativas en el volumen del hipocampo entre los grupos.
  • Las personas preocupadas informaron niveles más altos de depresión, ansiedad y apatía, y la apatía medió parcialmente las diferencias en el rendimiento de ARENA.

Conclusiones:

  • La preocupación por las SCC en adultos mayores se asocia con un aumento de los síntomas de estado de ánimo y motivación, lo que afecta el rendimiento en tareas cognitivas.
  • La tarea de navegación espacial (ARENA) puede ser sensible a los cambios cognitivos relacionados con el estado de ánimo, lo que podría reflejar la EA temprana.
  • Los hallazgos sugieren que el grupo de SCC "preocupado" podría representar a individuos que experimentan cambios de EA preclínica.