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Manifestaciones Clínicas

Alper Kursat Uysal1,2, Sai Shanmukh Varma Rudraraju1, Sai Santosh Reddy Danda1

  • 1University of Michigan-Dearborn, Dearborn, MI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los adultos mayores con amiloido-positividad (Aβ+) mostraron viajes de conducción más largos y más conducción nocturna, lo que sugiere posibles indicadores tempranos de la enfermedad de Alzheimer. Los conductores amiloido-negativos (Aβ-) completaron más viajes válidos, lo que indica una mejor operación del dispositivo.

Palabras clave:
conducciónAlzheimeradultos mayoresamiloidecomportamiento

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Área de la Ciencia:

  • Neurociencia
  • Gerontología
  • Seguridad en el Transporte

Sus antecedentes:

  • Cambios sutiles en la conducción en adultos mayores pueden indicar la enfermedad de Alzheimer (EA) temprana.
  • La positividad de amiloide en el cerebro es un fuerte indicador de EA.
  • Los datos de conducción naturalistas pueden revelar marcadores de deterioro cognitivo temprano.

Objetivo del estudio:

  • Distinguir a los adultos mayores con amiloido-positividad (Aβ+) de los individuos amiloido-negativos (Aβ-) utilizando el comportamiento de conducción.
  • Identificar atributos de conducción significativos basados en viajes para futuros modelos de aprendizaje automático.
  • Explorar la relación entre los patrones de conducción naturalistas y el estado de la amiloide.

Principales métodos:

  • Se analizaron datos de conducción naturalistas de 30 participantes Aβ+ y 30 Aβ- (2021-2024).
  • Se registraron viajes de conducción durante un mes utilizando un sistema de adquisición de datos facilitado por Internet.
  • Se examinaron 22 atributos basados en viajes, incluidos viajes válidos e inválidos, utilizando pruebas t estadísticas.

Principales resultados:

  • Los conductores Aβ- tuvieron un mayor porcentaje de viajes válidos (p=0.026).
  • Los conductores Aβ+ exhibieron una mayor duración promedio del viaje (p=0.037) y distancia (p=0.049).
  • Los participantes Aβ+ tuvieron un mayor porcentaje de viajes nocturnos entre semana (p=0.048).

Conclusiones:

  • Un mayor porcentaje de viajes válidos en los participantes Aβ- puede indicar una mejor operación del dispositivo.
  • Viajes más largos en individuos Aβ+ podrían sugerir una planificación de ruta menos eficiente.
  • El aumento de la conducción nocturna en el grupo Aβ+ puede indicar un mayor riesgo y posibles cambios cognitivos.