Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Validation of the care partner stress scale in the CAN-PROTECT study.

Journal of Alzheimer's disease : JAD·2026
Same author

The association between autistic traits and trajectories of anxiety in middle-aged and older adults: an 8-year growth mixture model analysis.

Nature. Mental health·2026
Same author

Mild Behavioural Impairment and Everyday Functioning in Cognitively Unimpaired Older Adults: Evidence From the CAN-PROTECT Study.

Journal of geriatric psychiatry and neurology·2026
Same author

Cross-sectional and longitudinal associations of self-perceptions of aging with physical activity in multimorbidity: The role of depressive symptoms.

Archives of gerontology and geriatrics·2026
Same author

Stakeholder perspectives on the potential benefits, risks, and implications of an interactive cognitive monitoring app for the identification and monitoring of cognitive decline in adults at risk of dementia.

BMC health services research·2026
Same author

Racial and Ethnic Representation in Dementia Clinical Trials Registered on ClinicalTrials.gov in the United States, United Kingdom, and Canada.

International journal of geriatric psychiatry·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Manifestaciones Clínicas

Clive G Ballard1, Ellie Pickering1, Abbie Palmer1

  • 1University of Exeter, Exeter, United Kingdom.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El estudio PROTECT-UK demuestra que las plataformas digitales pueden recopilar eficazmente datos longitudinales y realizar ensayos clínicos remotos en adultos mayores. Este enfoque garantiza una investigación de alta calidad, la participación de los participantes y la rentabilidad para futuros estudios.

Palabras clave:
envejecimientoinvestigación longitudinalensayos clínicos remotossalud digitalgenómica

Más Videos Relacionados

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Área de la Ciencia:

  • Gerontología e investigación sobre el envejecimiento; Salud digital y telemedicina; Investigación genómica y medicina personalizada.

Sus antecedentes:

  • La iniciativa PROTECT-UK estableció una cohorte en línea de adultos del Reino Unido para apoyar la recopilación de datos longitudinales a gran escala y de alta calidad.
  • Tenía como objetivo proporcionar una solución rentable y de bajo riesgo para ensayos clínicos remotos e híbridos en poblaciones de envejecimiento.

Objetivo del estudio:

  • Evaluar la viabilidad y efectividad de una plataforma digital para la recopilación de datos longitudinales en adultos mayores.
  • Facilitar ensayos clínicos remotos e híbridos, mejorando el reclutamiento y la retención.
  • Permitir la recopilación de muestras genómicas y biológicas para investigación avanzada.

Principales métodos:

  • Reclutamiento de adultos del Reino Unido mayores de 40 años a través de un sitio web y una aplicación dedicados.
  • Completación en línea de evaluaciones neuropsicológicas anuales (batería FLAME), datos de salud, estilo de vida y síntomas neuropsiquiátricos.
  • Recopilación remota de ADN y utilización de la plataforma para consentimiento para contacto y preselección para ensayos clínicos.
  • Estrategias de participación de los participantes que incluyen entrenamiento cognitivo y comunicación regular.

Principales resultados:

  • Más de 54.000 participantes inscritos, con 30.000 activos en la cohorte del Reino Unido; instancias internacionales en Noruega y Canadá.
  • Alta retención de participantes año tras año (hasta 80%) y retención en ensayos clínicos (hasta 95%) con una integridad de datos comparable a la de los ensayos presenciales.
  • Reclutamiento exitoso de más de 60.000 participantes en ensayos en línea, incluidos estudios de entrenamiento cognitivo y suplementos nutricionales (por ejemplo, Vitamina D, nitrato dietético).
  • Datos genómicos contribuyeron a estudios sobre esquizofrenia, riesgo de Alzheimer e identificaron cohortes con mutaciones GBA y homocigotos APOE4.

Conclusiones:

  • Los estudios de plataformas digitales pueden lograr la participación a largo plazo de los participantes a través de estrategias proactivas.
  • El estudio PROTECT valida la ejecución remota de ensayos clínicos eficientes y de alta calidad.
  • La recopilación remota de materiales genómicos y biológicos a través de plataformas digitales mejora significativamente los resultados de la investigación.