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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Manifestaciones Clínicas

Shalom K Henderson1, Ajay D Halai1, Kamen A Tsvetanov2

  • 1University of Cambridge, Cambridge, United Kingdom.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los pacientes con afasia primaria progresiva de variante logopénica (APPv) no presentan un déficit fonológico central. En cambio, sus dificultades de repetición se derivan de déficits en la memoria de trabajo, exacerbados por la pérdida auditiva.

Palabras clave:
afasia primaria progresiva de variante logopénicamemoria de trabajoprocesamiento fonológicopérdida auditivaneuroimagen

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Área de la Ciencia:

  • Neurolingüística
  • Neurociencia Cognitiva
  • Patología del Habla y del Lenguaje

Sus antecedentes:

  • La afasia primaria progresiva de variante logopénica (APPv) se caracteriza por un deterioro de la memoria fonológica a corto plazo.
  • La presencia de un déficit central en el procesamiento fonológico en la APPv sigue sin estar clara.
  • Este estudio investiga el procesamiento fonológico, la memoria de trabajo y sus correlatos neurales en la APPv.

Objetivo del estudio:

  • Determinar si la APPv implica un deterioro fonológico central más allá de los déficits de memoria a corto plazo.
  • Evaluar si la memoria de trabajo, la denominación por confrontación y el rendimiento fonológico reflejan déficits subyacentes.
  • Explorar la relación entre el rendimiento de la repetición y las diferencias cerebrales estructurales/funcionales.

Principales métodos:

  • Se comparó la repetición de palabras/pseudopalabras y la memoria a corto plazo en pacientes con enfermedad de Alzheimer típica (EA t), APPv y APPv avanzada (APPv+).
  • Se utilizaron análisis bayesianos para evaluar las diferencias y correlaciones entre grupos.
  • Se examinaron datos de neuroimagen estructural (materia gris) y funcional (conectividad).

Principales resultados:

  • No se encontraron diferencias significativas entre grupos en tareas fonológicas (repetición de palabras/pseudopalabras).
  • La pérdida auditiva autoinformada afectó significativamente la repetición de palabras y pseudopalabras, pero no la repetición de sílabas múltiples.
  • Las tareas fonológicas, la memoria de trabajo y la denominación por confrontación no mostraron correlaciones significativas, lo que sugiere mecanismos subyacentes distintos.

Conclusiones:

  • Los déficits en tareas fonológicas puras no dependen de la memoria de trabajo y están influenciados por la pérdida auditiva en la APPv y la EA t.
  • La APPv se caracteriza por un deterioro de la memoria de trabajo/buffer, no por un déficit fonológico central.
  • El rendimiento de la repetición está relacionado con la capacidad de la memoria de trabajo y potencialmente influenciado por la agudeza auditiva.