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Manifestaciones Clínicas

Idris Demirsoy1, Kellen K Petersen2, Bhargav Teja Nallapu3,4

  • 1Usak University, Usak, Turkey.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los síntomas depresivos impactan significativamente la función cognitiva, tanto subjetiva como objetiva, independientemente de los biomarcadores de la enfermedad de Alzheimer. Abordar el estado de ánimo es crucial para las estrategias de detección temprana e intervención en la investigación de la enfermedad de Alzheimer.

Palabras clave:
enfermedad de Alzheimerdepresióncogniciónbiomarcadorestrastornos del estado de ánimo

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Área de la Ciencia:

  • Neurociencia; Gerontología; Psiquiatría

Sus antecedentes:

  • El deterioro cognitivo subjetivo (SCI) predice la enfermedad de Alzheimer (AD). Los síntomas de estado de ánimo afectan negativamente las medidas cognitivas, independientemente de la patología de AD. La influencia independiente del estado de ánimo en la cognición requiere una mayor investigación.

Objetivo del estudio:

  • Examinar la relación entre los síntomas de estado de ánimo y las medidas cognitivas. Evaluar la función cognitiva utilizando el Cognitive Function Instrument (CFI) y el Preclinical Alzheimer Cognitive Composite (PACC). Tener en cuenta la carga de tau y amiloide en el análisis.

Principales métodos:

  • Análisis de 447 participantes del estudio A4 con escáneres de PET de tau y PET de amiloide. Evaluación de los síntomas depresivos (Geriatric Depression Scale, GDS) y los síntomas de ansiedad (State-Trait Anxiety Inventory, STAI). Modelos de regresión lineal múltiple ajustados por edad, educación y patología de AD (tauMTL y amiloide).

Principales resultados:

  • Los síntomas depresivos se relacionaron con una cognición subjetiva (CFI) y objetiva (PACC) más pobre. Los síntomas de ansiedad no mostraron una asociación significativa con las medidas cognitivas. La carga de tau predijo de forma independiente puntuaciones más bajas de PACC, mientras que la carga de amiloide no se correlacionó significativamente con los resultados cognitivos.

Conclusiones:

  • Los síntomas depresivos se asocian significativamente con la función cognitiva, independientemente de los biomarcadores de AD. Abordar los síntomas de estado de ánimo es vital para la investigación de AD y la detección temprana. Los síntomas de ansiedad tuvieron un impacto mínimo en la cognición en esta cohorte.