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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Troponins
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarcadores

Ningwei Hu1, Shan Wei1, Liangjun Dang1

  • 1The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los niveles altos de colesterol total y LDL-c, junto con niveles bajos de triglicéridos, se relacionan con el deterioro cognitivo en personas mayores de 65 años. Estos hallazgos sugieren que la dislipidemia puede acelerar el deterioro cognitivo en adultos mayores.

Palabras clave:
BiomarcadoresLípidos séricosDeterioro cognitivoAdultos mayoresDislipidemia

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Área de la Ciencia:

  • Neurology; Gerontology; Cardiovascular Science

Sus antecedentes:

  • Dyslipidemia is a known risk factor for cognitive impairments.
  • The specific impact of serum lipid levels on cognitive decline (CD) remained undetermined.

Objetivo del estudio:

  • To investigate the association between baseline serum lipid levels and cognitive decline over a 4-year period.
  • To explore the influence of age as an interaction effect on these associations.

Principales métodos:

  • A cohort study initiated in 2014 with follow-ups in 2016 and 2018.
  • Cognitive function assessed using the Mini-Mental State Examination (MMSE)
  • CD defined as a ≥2 point drop.
  • Serum lipids (TC, TG, HDL-c, LDL-c) categorized into three levels (Q1, Q2-Q3, Q4) based on quantiles.
  • Multivariate logistic regression, interaction effect, and subgroup analyses (<65 vs. ≥65 years) were employed.

Principales resultados:

  • 1,349 participants analyzed; 17.05% experienced CD.
  • In participants <65 years, no significant associations between lipid levels and CD were found.
  • In participants ≥65 years, high TC and LDL-c (Q4) and low TG (Q1) were associated with CD.
  • High TC (≥5.61 mmol/L) increased CD risk (OR=2.519), with a significant age interaction (OR=2.202).
  • Low TG (≤1.03 mmol/L) decreased CD risk (OR=0.318), with a significant age interaction (OR=0.344).
  • High LDL-c (≥3.81 mmol/L) increased CD risk (OR=2.367), with a significant age interaction (OR=2.237).

Conclusiones:

  • In individuals over 65, elevated baseline TC and LDL-c, and reduced baseline TG are associated with cognitive decline.
  • These lipid profiles may accelerate cognitive decline in the elderly population.
  • Targeting dyslipidemia could be a strategy to mitigate cognitive decline in older adults.