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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

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Manifestaciones Clínicas

Andrew M Kiselica¹, Sidonia Compton², Shayne S-H Lin³

¹University of Georgia, Athens, GA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

Resumen

Las medidas de dispersión cognitiva muestran potencial en la identificación de biomarcadores de la enfermedad de cuerpos de Lewy y la enfermedad de Alzheimer. Si bien las puntuaciones normalizadas son sensibles a la enfermedad, su fiabilidad test-retest en adultos mayores sanos es limitada.

Área de la Ciencia:

Neurociencia
Psicología Cognitiva
Gerontología

Conclusiones:

Las puntuaciones de dispersión cognitiva normalizadas demuestran potencial para la aplicación clínica, particularmente en la diferenciación de enfermedades neurodegenerativas específicas.
Si bien la fiabilidad test-retest puede ser una limitación en poblaciones cognitivamente sanas, las puntuaciones de dispersión muestran sensibilidad a los cambios relacionados con la enfermedad.
Estos hallazgos respaldan la utilidad de la dispersión cognitiva para comprender la heterogeneidad y la progresión de la enfermedad en trastornos neurodegenerativos.

Palabras clave:

disociación cognitiva enfermedad de Alzheimer enfermedad de cuerpos de Lewy puntuaciones normalizadas fiabilidad test-retest biomarcadores neurodegeneración

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