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Manifestaciones Clínicas

Sofia Marinou1, Natalie A Phillips1

  • 1Concordia University, Montreal, QC, Canada.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las personas con deterioro cognitivo subjetivo (SCD) y preocupación muestran una peor recuperación de la primacía, lo que indica un posible riesgo de enfermedad de Alzheimer (EA) temprana. Los patrones del efecto de posición en serie (SPE) pueden ayudar a detectar el deterioro cognitivo en esta población.

Palabras clave:
deterioro cognitivo subjetivoefecto de posición en serieAlzheimermemorianeuropsicología

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Área de la Ciencia:

  • Neurociencia
  • Gerontología
  • Psicología Cognitiva

Sus antecedentes:

  • El deterioro cognitivo subjetivo (SCD) es un deterioro cognitivo autoperceptivo, que predice potencialmente la enfermedad de Alzheimer (EA).
  • Las pruebas cognitivas estándar pueden pasar por alto cambios sutiles en personas con SCD.
  • El efecto de posición en serie (SPE), que implica la primacía (recuerdo de la lista temprana) y la recencia (recuerdo de la lista tardía), puede ofrecer medidas sensibles de la función cognitiva.

Objetivo del estudio:

  • Investigar si los patrones del efecto de posición en serie (SPE) difieren entre las personas con y sin deterioro cognitivo subjetivo (SCD).
  • Determinar si el SPE, particularmente el recuerdo de primacía, puede diferenciar a las personas con SCD que pueden tener un mayor riesgo de enfermedad de Alzheimer (EA).

Principales métodos:

  • Se utilizaron datos de la cohorte del Estudio Longitudinal Canadiense sobre el Envejecimiento (CLSA) (n=30,097).
  • Los participantes se clasificaron en tres grupos: sin SCD, SCD con preocupación y SCD sin preocupación.
  • Se evaluaron los patrones de SPE utilizando la Prueba de aprendizaje verbal auditivo de Rey (RAVLT).

Principales resultados:

  • No se encontraron diferencias significativas en las puntuaciones totales de recuerdo inmediato según el estado de SCD.
  • Surgieron diferencias significativas en el recuerdo de primacía y recencia entre los grupos.
  • Las personas con SCD y preocupación exhibieron un menor recuerdo de primacía en comparación con los controles, lo que sugiere posibles déficits en la memoria a largo plazo.

Conclusiones:

  • Un menor recuerdo de primacía en personas con SCD y preocupación sugiere que este patrón puede identificar a aquellas en riesgo de EA.
  • La evaluación de los patrones de SPE podría mejorar la detección temprana del deterioro cognitivo en poblaciones en riesgo.
  • El análisis de SPE ofrece una herramienta prometedora para comprender e identificar cambios cognitivos tempranos.