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Colecciones globales de muestras biológicas de estudios sobre tuberculosis: una revisión de alcance
Cara Adolph1, Simon C Mendelsohn2, Laura E Via3
1Centre for International Health, University of Otago, Dunedin, New Zealand.
The Lancet. Microbe
|December 25, 2025
Resumen
El establecimiento de biorrepositorios interconectados de muestras biológicas de estudios sobre tuberculosis es factible. Esta red podría acelerar significativamente el desarrollo de vacunas contra la tuberculosis al permitir investigaciones a gran escala sobre los mecanismos de la enfermedad y la inmunidad.
Área de la Ciencia:
- Inmunología
- Enfermedades Infecciosas
- Ciencia de Biorrepositorios
- Vacunología
Sus antecedentes:
- La comprensión de la inmunidad protectora y los mecanismos de la enfermedad es crucial pero incompleta para el desarrollo de vacunas contra la tuberculosis.
- Los estudios existentes sobre tuberculosis recolectan valiosas muestras biológicas que a menudo están aisladas.
- Una red coordinada de biorrepositorios de muestras podría cerrar las brechas de conocimiento.
Objetivo del estudio:
- Evaluar la factibilidad de crear una red interconectada de biorrepositorios de muestras de estudios sobre tuberculosis.
- Evaluar la disponibilidad de muestras biológicas y el interés de los investigadores en dicho recurso.
Principales métodos:
- Se realizó una revisión de alcance de estudios observacionales sobre tuberculosis y ensayos clínicos de vacunas (2014-2024).
- Se incluyeron estudios con >100 participantes que recolectaron muestras biológicas de casos, contactos o controles.
- Se contactó a los autores de los estudios para determinar la disponibilidad de muestras y el interés en biorrepositorios interconectados.
Principales resultados:
- Se identificaron 104 estudios observacionales y 18 ensayos de vacunas en 43 países.
- Estos estudios recolectaron muestras de más de 110.000 personas (casos, contactos, controles, participantes de ensayos).
- Las muestras recolectadas comúnmente incluyen sangre, ADN, ARN y esputo; el interés de los investigadores fue alto.
Conclusiones:
- Los biorrepositorios de muestras interconectados son factibles y muy deseados por los investigadores.
- Dicho recurso puede facilitar investigaciones a gran escala sobre la tuberculosis.
- Esta red tiene el potencial de acelerar significativamente el desarrollo de vacunas contra la tuberculosis.
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