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Manifestaciones Clínicas

Marcelo Jobet1,2, Veronica Perez1,2, Rodrigo A Santibanez2,3

  • 1Memory Clinic, Neurology Service, Complejo Asistencial Doctor Sótero del Río, Santiago, Chile.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

El Síndrome Cognitivo Afectivo Cerebeloso (CCAS) puede causar cambios cognitivos y de humor significativos debido a lesiones cerebelosas. El diagnóstico temprano utilizando herramientas como el CCAS-S es crucial para distinguirlo de las enfermedades neurodegenerativas.

Palabras clave:
Síndrome Cognitivo Afectivo Cerebelosolesiones cerebelosasdiagnósticoevaluación neurocognitivaresonancia magnética cerebral

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Área de la Ciencia:

  • Neurociencia; Neurología

Sus antecedentes:

  • El Síndrome Cognitivo Afectivo Cerebeloso (CCAS) se presenta con déficits cognitivos generalizados y desregulación del estado de ánimo.
  • Es causado por lesiones que afectan estructuras cerebelosas cruciales para la cognición y la emoción.
  • El diagnóstico implica la identificación de síntomas neuropsiquiátricos junto con lesiones cerebelosas, a menudo respaldado por la escala CCAS (CCAS-S).

Objetivo del estudio:

  • Presentar dos casos de Síndrome Cognitivo Afectivo Cerebeloso (CCAS) diagnosticados en 2024.
  • Destacar la presentación clínica y el proceso diagnóstico del CCAS.
  • Evaluar la utilidad del CCAS-S en el diagnóstico del CCAS.

Principales métodos:

  • Se evaluaron dos pacientes con lesiones cerebelosas y síntomas neuropsiquiátricos.
  • Se realizaron evaluaciones neurocognitivas, incluyendo el Montreal Cognitive Assessment (MoCA) y el CCAS-S.
  • Se utilizó resonancia magnética cerebral para identificar lesiones cerebelosas y descartar otras patologías.

Principales resultados:

  • Ambos pacientes presentaron alteraciones cognitivas y/o conductuales compatibles con CCAS.
  • La neuroimagen confirmó lesiones cerebelosas sin evidencia de neurodegeneración o patología supratentorial.
  • Las puntuaciones del CCAS-S respaldaron el diagnóstico clínico de CCAS en ambos casos.

Conclusiones:

  • El CCAS es una causa distinta de deterioro cognitivo y conductual, separada de las condiciones neurodegenerativas.
  • El diagnóstico preciso del CCAS requiere alta sospecha clínica, exclusión de causas alternativas y una evaluación neurocognitiva exhaustiva.
  • El CCAS-S es una herramienta valiosa para evaluar casos sospechosos de CCAS, lo que justifica una mayor investigación sobre la fisiopatología y el tratamiento del CCAS.