Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Instrumental Activities of Daily Living in Older Adults with Epilepsy: A Cross-Sectional and Longitudinal Multicenter Study.

medRxiv : the preprint server for health sciences·2026
Same author

A multiverse analysis of the logical memory test and plasma biomarkers of Alzheimer's disease.

Cortex; a journal devoted to the study of the nervous system and behavior·2026
Same author

Alzheimer's disease neuroimaging signature aids identification of cognitive impairment in older adults with early-onset epilepsy.

medRxiv : the preprint server for health sciences·2026
Same author

The IMPACT epilepsy Consortium: Exploring social drivers of health in epilepsy care to advance solution based initiatives.

Epilepsy & behavior : E&B·2026
Same author

Utility of the ADAS-Cog as a Cognitive Screening Tool in Older Adults with Epilepsy: A Multicenter Cohort Study.

medRxiv : the preprint server for health sciences·2026
Same author

Evaluating the interpretability of clinical speech AI models: Lessons from two user studies.

Computer speech & language·2026
Same journal

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Estimated labor market outcomes of people progressing from preclinical to early-stage Alzheimer's disease in the United States.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Manifestaciones Clínicas

Madeline R Hale1,2, Deling He3, Rebecca E Langhough4,5,6

  • 1Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Las personas con deterioro cognitivo leve (DCL) presentan patrones de habla distintivos, que incluyen una menor duración del recuerdo de historias (RH) y un aumento de las pausas, en comparación con las personas cognitivamente sanas (CS). Estas características acústicas del habla muestran potencial como biomarcadores tempranos de la enfermedad de Alzheimer (EA).

Palabras clave:
Deterioro cognitivo leveEnfermedad de AlzheimerBiomarcadores de hablaPausas en el hablaAnálisis acústicoDetección tempranaDeterioro cognitivoNeuroimagenProteínas amiloidesProteínas tau

Más Videos Relacionados

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Área de la Ciencia:

  • Neurología
  • Patología del Habla
  • Descubrimiento de Biomarcadores

Sus antecedentes:

  • Características sutiles del habla, como las pausas, son indicadores sensibles de la patología de la enfermedad de Alzheimer (EA), detectables mediante biomarcadores PET.
  • Investigaciones previas demostraron que las pausas silenciosas en la descripción de imágenes de la "Galleta" (GG) podían diferenciar a individuos cognitivamente sanos (CS) de individuos con deterioro cognitivo, y que estos últimos presentaban un habla y pausas más prolongadas.
  • Este estudio amplía la investigación de métodos automatizados de detección de pausas al dominio de las tareas de recuerdo de historias (RH).

Objetivo del estudio:

  • Investigar la utilidad del análisis acústico automatizado de las pausas silenciosas durante el recuerdo de historias (RH) como biomarcador potencial para la enfermedad de Alzheimer (EA) temprana.
  • Comparar las características del habla, específicamente las métricas de pausas y la duración, entre personas con deterioro cognitivo leve (DCL) y controles cognitivamente sanos (CS).
  • Evaluar la correlación de estas métricas del habla con biomarcadores PET (amiloide/tau), resultados de pruebas neuropsicológicas y estado cognitivo general.

Principales métodos:

  • Se seleccionaron cincuenta participantes (25 DCL, 25 CS), emparejados por datos demográficos clave, del Wisconsin Registry for Alzheimer's Prevention (WRAP) y del Wisconsin Alzheimer's Disease Research Center (WADRC).
  • Las grabaciones de audio de recuerdo de historias diferido (RH) (Logical Memory para WRAP, Craft Story para WADRC) se procesaron para extraer pausas silenciosas (>80 ms) utilizando el análisis de pausas del habla en MATLAB.
  • Los análisis estadísticos incluyeron pruebas de rangos con signo de Wilcoxon para comparaciones de grupos, correlaciones de Spearman para relaciones con datos clínicos/biomarcadores y análisis de regresión logística/ROC para predicción diagnóstica.

Principales resultados:

  • Los participantes cognitivamente sanos (CS) mostraron una mayor duración del recuerdo de historias (RH), mientras que el grupo con deterioro cognitivo leve (DCL) presentó una mayor duración media de las pausas y un mayor porcentaje de pausas.
  • La duración del habla en el RH se correlacionó significativamente con el rendimiento en diversas pruebas neuropsicológicas y con la carga de amiloide en PET.
  • La duración total del RH surgió como un predictor significativo del estado cognitivo (AUC=0.76), superando a la tarea de la "Galleta" (GG) en la diferenciación entre grupos cognitivos.

Conclusiones:

  • Las personas con DCL demuestran una menor duración del RH y una mayor frecuencia/duración de pausas en comparación con las personas CS, lo que podría reflejar déficits de memoria episódica.
  • Una menor duración del habla en las tareas de RH se asocia con niveles más altos de beta-amiloide, lo que sugiere un vínculo con la patología de la EA.
  • El análisis acústico automatizado de las pausas en el RH muestra ser prometedor como un marcador temprano sensible y no invasivo para la EA, mereciendo una mayor investigación en poblaciones diversas.