Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Beyond proximity: how food quality in dollar and grocery stores influences health.

BMC public health·2026
Same author

Dementia risk by metabolic health and obesity in two prospective cohorts.

BMC medicine·2026
Same author

Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease.

Neurotoxicology·2026
Same author

Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts.

International journal of obesity (2005)·2026
Same author

The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.

Psychological medicine·2026
Same author

Genetic and Environmental Associations Between Processing Speed and Executive Functions Across Adolescence and Established Adulthood.

Behavior genetics·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Manifestaciones Clínicas

Chandra A Reynolds1, Nathan A Gillespie2, Michael C Neale2

  • 1University of Colorado Boulder, Boulder, CO, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La heredabilidad del deterioro cognitivo leve amnésico en la edad adulta tardía se acerca a los niveles de la enfermedad de Alzheimer. Las puntuaciones de riesgo poligénico para la enfermedad de Alzheimer y la educación no predijeron significativamente el desarrollo del deterioro cognitivo leve en este estudio de gemelos.

Palabras clave:
heredabilidaddeterioro cognitivo leve amnésicodeterioro cognitivo leveenfermedad de Alzheimerestudios de gemelospuntuaciones de riesgo poligénicoeducación

Más Videos Relacionados

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Videos de Experimentos Relacionados

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Área de la Ciencia:

  • Gerontología; Genética; Neurociencia

Sus antecedentes:

  • El deterioro cognitivo leve (MCI) es un precursor de la enfermedad de Alzheimer (EA), con diversas estimaciones de heredabilidad.; La heredabilidad del MCI puede aumentar con un seguimiento más prolongado y la consideración de la estabilidad diagnóstica a lo largo del tiempo.; Es crucial investigar las contribuciones genéticas a través de puntuaciones poligénicas (PGS) para la EA y la educación.

Objetivo del estudio:

  • Determinar la heredabilidad del MCI en la edad adulta tardía dentro de una cohorte longitudinal de gemelos.; Evaluar la influencia de las puntuaciones poligénicas de la EA y el nivel educativo en el riesgo de MCI.; Examinar el impacto de la estabilidad diagnóstica en las estimaciones de heredabilidad del MCI.

Principales métodos:

  • Análisis longitudinal de 1593 gemelos varones (Vietnam Era Twin Study of Aging) de 52,1 a 78,5 años.; Diagnóstico de MCI basado en los criterios de Jak/Bondi, ajustado por la capacidad cognitiva temprana; se excluyeron los diagnósticos inestables.; Los análisis biométricos modelaron la heredabilidad, controlando la edad; se incorporaron las PGS de la EA y la educación.

Principales resultados:

  • La heredabilidad del deterioro cognitivo leve amnésico (aMCI) se estimó en 57,9 % (aumentando a 61,1 % al excluir diagnósticos inestables).; La heredabilidad general del MCI fue del 42,1 % (aumentando a 46,9 %), mientras que la heredabilidad del MCI no amnésico no fue estimable.; Las puntuaciones poligénicas para la EA y la educación mostraron una asociación mínima (<1 %) con el riesgo general o de aMCI.

Conclusiones:

  • La heredabilidad del deterioro cognitivo leve amnésico en la edad adulta tardía es comparable a las estimaciones de la EA, lo que resalta una influencia genética significativa.; Las puntuaciones poligénicas actuales para la EA y la educación no capturan adecuadamente los riesgos genéticos para el MCI.; Se necesita más investigación para identificar los factores genéticos específicos que contribuyen al desarrollo del MCI.